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cep70 centrosomal protein 70 [ Danio rerio (zebrafish) ]

Gene ID: 100136857, updated on 9-Dec-2024

Summary

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Official Symbol
cep70provided by ZNC
Official Full Name
centrosomal protein 70provided by ZNC
Primary source
ZFIN:ZDB-GENE-070705-311
See related
Ensembl:ENSDARG00000076965 AllianceGenome:ZFIN:ZDB-GENE-070705-311
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-170g11.4
Summary
Predicted to enable gamma-tubulin binding activity. Acts upstream of or within cilium assembly and epithelial cilium movement involved in determination of left/right asymmetry. Located in extracellular region. Is expressed in central canal; hair cell; otic vesicle; pronephric duct; and solid lens vesicle. Orthologous to human CEP70 (centrosomal protein 70). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See cep70 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (12603811..12626056, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (12579501..12601279, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488914 Neighboring gene uncharacterized LOC137489012 Neighboring gene metabolism of cobalamin associated Da Neighboring gene adenosine deaminase RNA specific B1a Neighboring gene uncharacterized LOC110438271 Neighboring gene SLX9 ribosome biogenesis factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos. Wilkinson CJ, et al. BMC Cell Biol, 2009 Mar 2. PMID 19254375, Free PMC Article
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cep70 and Cep131 contribute to ciliogenesis in many tissues in the zebrafish embryo.
    Title: Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cilium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosomal protein of 70 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114576.1 → NP_001108048.1  centrosomal protein of 70 kDa

    See identical proteins and their annotated locations for NP_001108048.1

    Status: PROVISIONAL

    Source sequence(s)
    BC154450
    UniProtKB/TrEMBL
    A0A8M9PDS2, A8WFT5
    Related
    ENSDARP00000104406.3, ENSDART00000115344.5
    Conserved Domains (2) summary
    PTZ00400
    Location:183 → 325
    PTZ00400; DnaK-type molecular chaperone; Provisional
    pfam15066
    Location:53 → 167
    CAGE1; Cancer-associated gene protein 1 family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    12603811..12626056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017353091.3 → XP_017208580.1  centrosomal protein of 70 kDa isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z3B7, A0A8M9P470
Nucleotide Protein
Heading Accession and Version

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