RELA RELA proto-oncogene, NF-kB subunit [Sus scrofa (pig)] - Gene

Summary

Official Symbol: RELAprovided by VGNC
Official Full Name: RELA proto-oncogene, NF-kB subunitprovided by VGNC
Primary source: VGNC:VGNC:92203
See related: Ensembl:ENSSSCG00000012981
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Annotation information: Annotation category: partial on reference assembly
Expression: Ubiquitous expression in lung (RPKM 31.2), ovary (RPKM 31.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	2	NC_010444.4 (6594869..6602684)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	2	NC_010444.3 (5699452..5707267, complement)

Chromosome 2 - NC_010444.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pseudorabies Virus Infection Triggers NF-kappaB Activation via the DNA Damage Response but Actively Inhibits NF-kappaB-Dependent Gene Expression.
Title: Pseudorabies Virus Infection Triggers NF-κB Activation via the DNA Damage Response but Actively Inhibits NF-κB-Dependent Gene Expression.
Integrin beta3, a RACK1 interacting protein, is critical for porcine reproductive and respiratory syndrome virus infection and NF-kappaB activation in Marc-145 cells.
Title: Integrin β3, a RACK1 interacting protein, is critical for porcine reproductive and respiratory syndrome virus infection and NF-κB activation in Marc-145 cells.
Porcine RACK1 negatively regulates the infection of classical swine fever virus and the NF-kappaB activation in PK-15 cells.
Title: Porcine RACK1 negatively regulates the infection of classical swine fever virus and the NF-κB activation in PK-15 cells.
P65 Targets FGFR1 to Regulate the Survival of Ovarian Granulosa Cells.
Title: P65 Targets FGFR1 to Regulate the Survival of Ovarian Granulosa Cells.
NF-kappaB activation was a major contributor to Porcine transmissible gastroenteritis virus infection-induced inflammation, and nonstructural protein 2 (Nsp2) was the key viral protein involved in the regulation of inflammation, with amino acids 1-120 playing a critical role in activating NF-kappaB.
Title: Porcine transmissible gastroenteritis virus nonstructural protein 2 contributes to inflammation via NF-κB activation.
TRAF6 is a novel NS3-interacting protein that inhibits classical swine fever virus replication via activation of NF-kappaB-signaling pathways.
Title: TRAF6 is a novel NS3-interacting protein that inhibits classical swine fever virus replication.
NF-kappaB signaling pathway was activated by transmissible gastroenteritis virus infection.NF-kappaB has 4 binding sites in the FcRn promoter.
Title: TGEV infection up-regulates FcRn expression via activation of NF-κB signaling.
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB/ TNF-alpha pathway in cardiomyocytes.
Title: Effects of Trimetazidine on PDCD4/NF-κB/TNF-α Pathway in Coronary Microembolization.
Transmissible gastroenteritis virus infection activates NF-kappaB.
Title: Transmissible gastroenteritis virus infection induces NF-κB activation through RLR-mediated signaling.
Zinc finger nuclease in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine Fever.
Title: Mammalian interspecies substitution of immune modulatory alleles by genome editing.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to stress	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: transcription factor p65

Names: NF-kappaB transcription factor p65 subunit; v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114281.1 → NP_001107753.1 transcription factor p65

See identical proteins and their annotated locations for NP_001107753.1

Status: PROVISIONAL

Source sequence(s)

EU399817

UniProtKB/TrEMBL

A0A4X1UL81, B0LXP3, F2QA75, I3LV53

Related

ENSSSCP00000013805.4, ENSSSCT00000014191.6

Conserved Domains (3) summary

cd07885
Location:19 → 187

RHD-n_RelA; N-terminal sub-domain of the Rel homology domain (RHD) of RelA

cd01177
Location:194 → 290

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cl26464
Location:255 → 524

Atrophin-1; Atrophin-1 family