Hbbl1 hemoglobin subunit beta like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hbbl1provided by RGD
Official Full Name: hemoglobin subunit beta like 1provided by RGD
Primary source: RGD:2290038
See related: AllianceGenome:RGD:2290038
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable heme binding activity; metal ion binding activity; and oxygen carrier activity. Predicted to be involved in nitric oxide transport and oxygen transport. Predicted to be part of hemoglobin complex. Human ortholog(s) of this gene implicated in several diseases, including acute chest syndrome; congenital hemolytic anemia (multiple); polycythemia (multiple); sickle cell disease (multiple); and thalassemia (multiple). Orthologous to human HBB (hemoglobin subunit beta) and HBD (hemoglobin subunit delta). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Spleen (RPKM 187243.0), Lung (RPKM 41900.0) and 1 other tissue See more
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Genomic context

Location:: 1q32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (167648859..167650235, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (158236972..158238348, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (168957460..168958836)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:516684

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:531320

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:516509

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:499134

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbon dioxide transport	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide transport	ISO Inferred from Sequence Orthology more info
involved_in oxygen transport	IEA Inferred from Electronic Annotation more info
involved_in oxygen transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of hemoglobin complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: hemoglobin subunit beta-2

Names: III beta-2 globin; beta globin minor; beta-2-globin; beta-min-globin chain; hemoglobin beta chain, minor-form; hemoglobin beta-2 chain; three beta-2 globin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113223.2 → NP_001106694.1 hemoglobin subunit beta-2

See identical proteins and their annotated locations for NP_001106694.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P11517

UniProtKB/TrEMBL

A0A0G2JTW9, A0A1K0FUA6, A0A1K0GGD1

Conserved Domains (1) summary

cd08925
Location:8 → 146

Hb-beta-like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits