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ZNF667-AS1 ZNF667 antisense RNA 1 (head to head) [ Homo sapiens (human) ]

Gene ID: 100128252, updated on 10-Dec-2024

Summary

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Official Symbol
ZNF667-AS1provided by HGNC
Official Full Name
ZNF667 antisense RNA 1 (head to head)provided by HGNC
Primary source
HGNC:HGNC:44321
See related
Ensembl:ENSG00000166770 AllianceGenome:HGNC:44321
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MORT
Expression
Broad expression in thyroid (RPKM 15.6), brain (RPKM 15.5) and 25 other tissues See more
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Genomic context

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See ZNF667-AS1 in Genome Data Viewer
Location:
19q13.43
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56477874..56495437)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59572310..59589873)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56989243..57006806)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF582 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15119 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11069 Neighboring gene zinc finger protein 583 Neighboring gene zinc finger protein 667 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:56968363-56969562 Neighboring gene uncharacterized LOC105372471 Neighboring gene uncharacterized LOC124904776 Neighboring gene zinc finger protein 471 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:57037017-57038216 Neighboring gene ZFP28 divergent transcript Neighboring gene ZFP28 zinc finger protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers. Vrba L, et al. Epigenetics, 2015. PMID 26646903, Free PMC Article
  2. LncRNA MORT negatively regulates FGF1 to suppress malignant progression of breast cancer. Yang Q, et al. Eur Rev Med Pharmacol Sci, 2021 Oct. PMID 34730198
  3. Independent prognostic Factor of low-expressed LncRNA ZNF667-AS1 for cervical cancer and inhibitory function on the proliferation of cervical cancer. Zhao LP, et al. Eur Rev Med Pharmacol Sci, 2017 Dec. PMID 29243775
  4. IncRNA ZNF667-AS1 Suppresses Epithelial Mesenchymal Transformation by Targeting TGF-β1 in Oral Squamous Cell Carcinoma. Zhao J, et al. Clin Lab, 2021 Jul 1. PMID 34258957
  5. LncRNA MORT Overexpression Inhibits Cancer Cell Migration and Invasion in Hepatocellular Carcinoma by Downregulating NOTCH1. Lu X, et al. Cancer Biother Radiopharm, 2022 Sep. PMID 33493420

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA ZNF667-AS1 Targets miR-523-3p/KIF5C Axis to Hinder Colon Cancer Progression.
    Title: LncRNA ZNF667-AS1 Targets miR-523-3p/KIF5C Axis to Hinder Colon Cancer Progression.
  2. LncRNA MORT Overexpression Inhibits Cancer Cell Migration and Invasion in Hepatocellular Carcinoma by Downregulating NOTCH1.
    Title: LncRNA MORT Overexpression Inhibits Cancer Cell Migration and Invasion in Hepatocellular Carcinoma by Downregulating NOTCH1.
  3. Regulation of IncRNA ZNF667-AS1 in Proliferation and Invasion of Esophageal Squamous Cell Carcinoma Cells via Mediating ceRNA Network.
    Title: Regulation of IncRNA ZNF667-AS1 in Proliferation and Invasion of Esophageal Squamous Cell Carcinoma Cells via Mediating ceRNA Network.
  4. LncRNA ZNF667-AS1 alleviates rheumatoid arthritis by sponging miR-523-3p and inactivating the JAK/STAT signalling pathway.
    Title: LncRNA ZNF667-AS1 alleviates rheumatoid arthritis by sponging miR-523-3p and inactivating the JAK/STAT signalling pathway.
  5. LncRNA MORT negatively regulates FGF1 to suppress malignant progression of breast cancer.
    Title: LncRNA MORT negatively regulates FGF1 to suppress malignant progression of breast cancer.
  6. Hypermethylation of Genes in New Long Noncoding RNA in Ovarian Tumors and Metastases: A Dual Effect.
    Title: Hypermethylation of Genes in New Long Noncoding RNA in Ovarian Tumors and Metastases: A Dual Effect.
  7. lncRNA ZNF667-AS1 (NR_036521.1) inhibits the progression of colorectal cancer via regulating ANK2/JAK2 expression.
    Title: lncRNA ZNF667-AS1 (NR_036521.1) inhibits the progression of colorectal cancer via regulating ANK2/JAK2 expression.
  8. Analysis of Long Noncoding RNA ZNF667-AS1 as a Potential Biomarker for Diagnosis and Prognosis of Glioma Patients.
    Title: Analysis of Long Noncoding RNA ZNF667-AS1 as a Potential Biomarker for Diagnosis and Prognosis of Glioma Patients.
  9. ZNF667-AS1, a positively regulating MEGF10, inhibits the progression of uveal melanoma by modulating cellular aggressiveness.
    Title: ZNF667-AS1, a positively regulating MEGF10, inhibits the progression of uveal melanoma by modulating cellular aggressiveness.
  10. IncRNA ZNF667-AS1 Suppresses Epithelial Mesenchymal Transformation by Targeting TGF-beta1 in Oral Squamous Cell Carcinoma.
    Title: IncRNA ZNF667-AS1 Suppresses Epithelial Mesenchymal Transformation by Targeting TGF-β1 in Oral Squamous Cell Carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • Mortal Obligate RNA Transcript

Clone Names

  • MGC9913, AC004696.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_036521.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC098795, AW955601, BC110411
    Related
    ENST00000585445.1

  2. NR_036522.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice donor site, compared to variant 1.
    Source sequence(s)
    AC004696, AC098795
    Related
    ENST00000691191.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    56477874..56495437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    59572310..59589873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198879.1: Suppressed sequence

    Description
    NM_198879.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version

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