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Nadk NAD kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 100125370, updated on 14-Nov-2024

Summary

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Symbol
Nadkprovided by RGD
Full Name
NAD kinaseprovided by RGD
Primary source
RGD:1642420
See related
EnsemblRapid:ENSRNOG00000016936 AllianceGenome:RGD:1642420
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NAD+ kinase activity. Involved in NADP biosynthetic process and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Orthologous to human NADK (NAD kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 321.0), Adrenal (RPKM 304.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nadk in Genome Data Viewer
Location:
5q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171427973..171458586)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166145708..166176328)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172984930..173015505)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 52 Neighboring gene G protein subunit beta 1 Neighboring gene uncharacterized LOC120103052 Neighboring gene ATP synthase peripheral stalk subunit d, pseudogene 1 Neighboring gene uncharacterized LOC134487048 Neighboring gene solute carrier family 35, member E2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells. Gray JP, et al. Am J Physiol Endocrinol Metab, 2012 Jul 15. PMID 22550069, Free PMC Article
  2. MNADK, a Long-Awaited Human Mitochondrion-Localized NAD Kinase. Zhang R. J Cell Physiol, 2015 Aug. PMID 25641397
  3. Structural and functional characterization of human NAD kinase. Lerner F, et al. Biochem Biophys Res Commun, 2001 Oct 19. PMID 11594753
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109551

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in NAD metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NADP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NADP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
NAD kinase
NP_001103148.1
XP_006239575.1
XP_006239576.1
XP_038965017.1
XP_038965018.1
XP_038965019.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109678.1 → NP_001103148.1  NAD kinase

    See identical proteins and their annotated locations for NP_001103148.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/TrEMBL
    A0A8I5ZN26, A6IUQ7, F7EXV6
    Conserved Domains (1) summary
    cl01255
    Location:98 → 429
    DAGK_cat; Diacylglycerol kinase catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    171427973..171458586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109091.2 → XP_038965019.1  NAD kinase isoform X5

    Conserved Domains (1) summary
    cl01255
    Location:130 → 353
    DAGK_cat; Diacylglycerol kinase catalytic domain

  2. XM_039109089.2 → XP_038965017.1  NAD kinase isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZN26
    Conserved Domains (1) summary
    cl28462
    Location:128 → 472
    pnk; bifunctional NADP phosphatase/NAD kinase

  3. XM_006239513.5 → XP_006239575.1  NAD kinase isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZN26, A0A8I6AFT7
    Related
    ENSRNOP00000093005.1, ENSRNOT00000094609.2
    Conserved Domains (1) summary
    cl01255
    Location:130 → 461
    DAGK_cat; Diacylglycerol kinase catalytic domain

  4. XM_039109090.2 → XP_038965018.1  NAD kinase isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZN26, Q5FVF8
    Related
    ENSRNOP00000095842.2, ENSRNOT00000101792.2
    Conserved Domains (1) summary
    cl28462
    Location:96 → 440
    pnk; bifunctional NADP phosphatase/NAD kinase

  5. XM_006239514.4 → XP_006239576.1  NAD kinase isoform X4

    See identical proteins and their annotated locations for XP_006239576.1

    UniProtKB/TrEMBL
    A0A8I5ZN26, A6IUQ7, F7EXV6
    Conserved Domains (1) summary
    cl01255
    Location:98 → 429
    DAGK_cat; Diacylglycerol kinase catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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