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znrf2a zinc and ring finger 2a [ Danio rerio (zebrafish) ]

Gene ID: 100124611, updated on 4-Jan-2025

Summary

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Official Symbol
znrf2aprovided by ZNC
Official Full Name
zinc and ring finger 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070820-15
See related
Ensembl:ENSDARG00000077855 AllianceGenome:ZFIN:ZDB-GENE-070820-15
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:171663
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K48-linked ubiquitination. Predicted to be located in lysosome. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Is expressed in telencephalon and yolk syncytial layer. Orthologous to human ZNRF2 (zinc and ring finger 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See znrf2a in Genome Data Viewer
Location:
chromosome: 19
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (1934481..1947403, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (1984627..1997628, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:ch211-149a19.3 Neighboring gene uncharacterized LOC137488428 Neighboring gene dentin sialophosphoprotein-like Neighboring gene maturin, neural progenitor differentiation regulator homolog (Xenopus) Neighboring gene SH3-domain binding protein 5a (BTK-associated)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptional responses and mechanisms of copper nanoparticle toxicology on zebrafish embryos. Zhang Y, et al. J Hazard Mater, 2018 Feb 15. PMID 30216965
  2. Copper elevated embryonic hemoglobin through reactive oxygen species during zebrafish erythrogenesis. Zhou XY, et al. Aquat Toxicol, 2016 Jun. PMID 26991749
  3. Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis. Zhao G, et al. Cell Commun Signal, 2020 Mar 14. PMID 32169084, Free PMC Article
  4. Transcriptional profiles and copper stress responses in zebrafish cox17 mutants. Sun H, et al. Environ Pollut, 2020 Jan. PMID 31662245
  5. Atp7b deficiency induces zebrafish eye developmental defects. Wu Y, et al. Metallomics, 2023 May 2. PMID 37070960

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase znrf2-like
NP_001096107.1
XP_005170036.1
XP_017207661.1
XP_068071114.1
XP_068071115.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102637.1 → NP_001096107.1  E3 ubiquitin-protein ligase znrf2-like

    See identical proteins and their annotated locations for NP_001096107.1

    Status: PROVISIONAL

    Source sequence(s)
    BC150372
    UniProtKB/TrEMBL
    A7E2J2
    Related
    ENSDARP00000125859.1, ENSDART00000134074.2
    Conserved Domains (1) summary
    pfam13639
    Location:136 → 176
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    1934481..1947403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017352172.3 → XP_017207661.1  E3 ubiquitin-protein ligase znrf2-like isoform X2

    UniProtKB/TrEMBL
    A0A0R4IZG3, A0A8M2BHB6, B8JKY5
    Conserved Domains (1) summary
    pfam13639
    Location:136 → 176
    zf-RING_2; Ring finger domain

  2. XM_005169979.5 → XP_005170036.1  E3 ubiquitin-protein ligase znrf2-like isoform X2

    UniProtKB/TrEMBL
    A0A0R4IZG3, A0A8M2BHB6, B8JKY5
    Related
    ENSDARP00000104121.2, ENSDART00000113951.4
    Conserved Domains (1) summary
    pfam13639
    Location:136 → 176
    zf-RING_2; Ring finger domain

  3. XM_068215013.1 → XP_068071114.1  E3 ubiquitin-protein ligase znrf2-like isoform X1

    Related
    ENSDARP00000125764.1, ENSDART00000151293.3

  4. XM_068215014.1 → XP_068071115.1  E3 ubiquitin-protein ligase znrf2-like isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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