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kif3b kinesin family member 3B [ Danio rerio (zebrafish) ]

Gene ID: 100101641, updated on 4-Jan-2025

Summary

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Official Symbol
kif3bprovided by ZNC
Official Full Name
kinesin family member 3Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050119-3
See related
Ensembl:ENSDARG00000101120 AllianceGenome:ZFIN:ZDB-GENE-050119-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:165446
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in cilium assembly and photoreceptor cell development. Acts upstream of or within several processes, including nose development; photoreceptor cell outer segment organization; and sensory system development. Part of kinesin complex. Is expressed in forerunner cell group and retina. Human ortholog(s) of this gene implicated in retinitis pigmentosa 89. Orthologous to human KIF3B (kinesin family member 3B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See kif3b in Genome Data Viewer
Location:
chromosome: 23
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (7710624..7736479)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (7776660..7802507)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene pleiomorphic adenoma gene-like 2 Neighboring gene protein O-fucosyltransferase 1 Neighboring gene protein-L-isoaspartate O-methyltransferase domain-containing protein 2 Neighboring gene myelin transcription factor 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of a wide spectrum of ciliary gene mutations in nonsyndromic biliary atresia patients implicates ciliary dysfunction as a novel disease mechanism. Lam WY, et al. EBioMedicine, 2021 Sep. PMID 34455394, Free PMC Article
  2. Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy. Cogné B, et al. Am J Hum Genet, 2020 Jun 4. PMID 32386558, Free PMC Article
  3. Kinesin-2 family in vertebrate ciliogenesis. Zhao C, et al. Proc Natl Acad Sci U S A, 2012 Feb 14. PMID 22308397, Free PMC Article
  4. β-SNAP activity in the outer segment growth period is critical for preventing BNip1-dependent apoptosis in zebrafish photoreceptors. Nishiwaki Y, et al. Sci Rep, 2020 Oct 15. PMID 33060680, Free PMC Article
  5. Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis. Zhang X, et al. Nat Genet, 2018 Dec. PMID 30420648

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.
    Title: Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.
  2. Knock-down of KIF3B Causes Early Embryonic Defects.
    Title: Different roles for KIF17 and kinesin II in photoreceptor development and maintenance.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inner ear development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within inner ear development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuromast development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nose development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in opsin transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in photoreceptor cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photoreceptor cell outer segment organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pronephros development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of kinesin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF3B
NP_001093615.1
XP_005174158.1
XP_068072748.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100145.1 → NP_001093615.1  kinesin-like protein KIF3B

    See identical proteins and their annotated locations for NP_001093615.1

    Status: PROVISIONAL

    Source sequence(s)
    BC146722
    Related
    ENSDARP00000150665.1, ENSDART00000186852.1
    Conserved Domains (4) summary
    cd01371
    Location:15 → 341
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam00225
    Location:15 → 341
    Kinesin; Kinesin motor domain
    cd16269
    Location:500 → 511
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:425 → 523
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    7710624..7736479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005174101.5 → XP_005174158.1  kinesin-like protein KIF3B isoform X2

    UniProtKB/TrEMBL
    A0A8M2BLD4
    Conserved Domains (4) summary
    cd01371
    Location:15 → 341
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam00225
    Location:15 → 341
    Kinesin; Kinesin motor domain
    cd16269
    Location:500 → 511
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:425 → 523
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. XM_068216647.1 → XP_068072748.1  kinesin-like protein KIF3B isoform X1

    UniProtKB/Swiss-Prot
    A6H8R7, F1QN54
    Related
    ENSDARP00000133077.1, ENSDART00000168199.3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1QN54.1 GenPept UniProtKB/Swiss-Prot:F1QN54

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