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Cyp4a32 cytochrome P450, family 4, subfamily a, polypeptide 32 [ Mus musculus (house mouse) ]

Gene ID: 100040843, updated on 27-Nov-2024

Summary

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Official Symbol
Cyp4a32provided by MGI
Official Full Name
cytochrome P450, family 4, subfamily a, polypeptide 32provided by MGI
Primary source
MGI:MGI:3717148
See related
Ensembl:ENSMUSG00000063929 AllianceGenome:MGI:3717148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable monooxygenase activity. Predicted to be involved in carboxylic acid metabolic process; kidney development; and positive regulation of icosanoid secretion. Predicted to be located in apical plasma membrane and cytoplasm. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 53.2), kidney adult (RPKM 48.4) and 1 other tissue See more
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Genomic context

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See Cyp4a32 in Genome Data Viewer
Location:
4 D1; 4 53.06 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115458124..115479704)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115600927..115622507)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 31 Neighboring gene cytochrome P450, family 4, subfamily b, polypeptide 1, pseudogene 2 Neighboring gene cytochrome P450, family 4, subfamily b, polypeptide 1 Neighboring gene eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alkane 1-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alkane 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonate epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonate monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonate monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables leukotriene-B4 20-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acid omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in arachidonate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arachidonate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in epoxygenase P450 pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in icosanoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in icosanoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in kidney development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lauric acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lauric acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of icosanoid secretion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytochrome P450, family 4, subfamily a, polypeptide 32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100181.2 → NP_001093651.1  cytochrome P450, family 4, subfamily a, polypeptide 32 isoform 1

    See identical proteins and their annotated locations for NP_001093651.1

    Status: VALIDATED

    Source sequence(s)
    AL626805
    Consensus CDS
    CCDS38844.1
    UniProtKB/TrEMBL
    A2A8T1, A2A977
    Related
    ENSMUSP00000081369.6, ENSMUST00000084342.6
    Conserved Domains (1) summary
    pfam00067
    Location:52 → 503
    p450; Cytochrome P450

  2. NM_001425042.1 → NP_001411971.1  cytochrome P450, family 4, subfamily a, polypeptide 32 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626805

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115458124..115479704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319878.2 → XP_017175367.1  cytochrome P450, family 4, subfamily a, polypeptide 32 isoform X1

    UniProtKB/TrEMBL
    Q9QYM6
    Conserved Domains (1) summary
    pfam00067
    Location:52 → 407
    p450; Cytochrome P450

  2. XM_006502613.3 → XP_006502676.1  cytochrome P450, family 4, subfamily a, polypeptide 32 isoform X3

    Conserved Domains (1) summary
    pfam00067
    Location:1 → 313
    p450; Cytochrome P450

  3. XM_030252999.1 → XP_030108859.1  cytochrome P450, family 4, subfamily a, polypeptide 32 isoform X3

    Conserved Domains (1) summary
    pfam00067
    Location:1 → 313
    p450; Cytochrome P450

RNA

  1. XR_003954855.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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