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mink1 misshapen-like kinase 1 [ Danio rerio (zebrafish) ]

Gene ID: 100038799, updated on 4-Jan-2025

Summary

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Official Symbol
mink1provided by ZNC
Official Full Name
misshapen-like kinase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-060526-45
See related
Ensembl:ENSDARG00000035360 AllianceGenome:ZFIN:ZDB-GENE-060526-45
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
msn3; zgc:162163; si:ch211-147a23.2
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Orthologous to human MINK1 (misshapen like kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See mink1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (38301906..38385380, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (37701753..37785380, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain-containing protein 5B Neighboring gene guanine nucleotide binding protein (G protein), beta polypeptide 2 Neighboring gene uncharacterized LOC137490148 Neighboring gene phospholipase D2 Neighboring gene cholinergic receptor, nicotinic, epsilon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila. Köppen M, et al. Development, 2006 Jul. PMID 16794032
  2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
misshapen-like kinase 1
NP_001083048.2
NP_001300770.1
XP_017211494.1
XP_017211495.1
XP_017211497.1
XP_017211499.1
XP_021331645.1
XP_021331646.1
XP_021331647.1
XP_021331648.1
XP_068077151.1
XP_068077152.1
XP_068077153.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089579.2 → NP_001083048.2  misshapen-like kinase 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BX324194
    UniProtKB/TrEMBL
    A0A8M1NDD4, F1REC7
    Related
    ENSDARP00000051232.5, ENSDART00000051233.5
    Conserved Domains (1) summary
    cl21453
    Location:8 → 139
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001313841.1 → NP_001300770.1  misshapen-like kinase 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BX324194
    UniProtKB/TrEMBL
    A0A2R8QM71, A0A8M1P738
    Related
    ENSDARP00000156553.1, ENSDART00000188573.1
    Conserved Domains (3) summary
    smart00036
    Location:955 → 1253
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    38301906..38385380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017356008.3 → XP_017211497.1  misshapen-like kinase 1 isoform X7

    UniProtKB/TrEMBL
    A0A8M6YYZ8
    Related
    ENSDARP00000113008.1, ENSDART00000135260.3

  2. XM_017356010.3 → XP_017211499.1  misshapen-like kinase 1 isoform X10

    UniProtKB/TrEMBL
    A0A8M6Z0G7

  3. XM_068221052.1 → XP_068077153.1  misshapen-like kinase 1 isoform X11

  4. XM_068221051.1 → XP_068077152.1  misshapen-like kinase 1 isoform X9

  5. XM_017356006.3 → XP_017211495.1  misshapen-like kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8M6Z686

  6. XM_017356005.3 → XP_017211494.1  misshapen-like kinase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M6YY39

  7. XM_068221050.1 → XP_068077151.1  misshapen-like kinase 1 isoform X8

  8. XM_021475973.2 → XP_021331648.1  misshapen-like kinase 1 isoform X6

    UniProtKB/TrEMBL
    A0A8M9PX03
    Conserved Domains (2) summary
    smart00036
    Location:960 → 1258
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  9. XM_021475971.2 → XP_021331646.1  misshapen-like kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q813
    Conserved Domains (2) summary
    smart00036
    Location:994 → 1292
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  10. XM_021475972.2 → XP_021331647.1  misshapen-like kinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PJK9
    Conserved Domains (2) summary
    smart00036
    Location:988 → 1286
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  11. XM_021475970.2 → XP_021331645.1  misshapen-like kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QDG2
    Conserved Domains (2) summary
    smart00036
    Location:996 → 1294
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394597.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    37049..119898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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