dkk3b dickkopf WNT signaling pathway inhibitor 3b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dkk3bprovided by ZNC
Official Full Name: dickkopf WNT signaling pathway inhibitor 3bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061207-74
See related: Ensembl:ENSDARG00000070683 AllianceGenome:ZFIN:ZDB-GENE-061207-74
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dkk3; si:dkey-80c24.6
Summary: Predicted to enable co-receptor binding activity and receptor antagonist activity. Acts upstream of or within lens development in camera-type eye. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in choroid plexus; digestive system; fin bud; pronephros; and tela chorioidea. Orthologous to human DKK3 (dickkopf WNT signaling pathway inhibitor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (16132575..16146845, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (16036175..16050445, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a novel intronic microRNA, miR-In300, which is derived from I300 of the first intron of zebrafish myf5, enables significant repression of myf5 promoter activity through silencing the long isoform of the Dickkopfs-3 gene.
Title: Novel intronic microRNA represses zebrafish myf5 promoter activity through silencing dickkopf-3 gene.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables co-receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dickkopf-related protein 3b

Names: dickkopf homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.