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Rnaset2a ribonuclease T2A [ Mus musculus (house mouse) ]

Gene ID: 100037283, updated on 27-Nov-2024

Summary

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Official Symbol
Rnaset2aprovided by MGI
Official Full Name
ribonuclease T2Aprovided by MGI
Primary source
MGI:MGI:1915445
See related
Ensembl:ENSMUSG00000095687 AllianceGenome:MGI:1915445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnaset2; RNASE6PL; 0610007O07Rik; 4833423A10Rik; 4930532K22Rik
Summary
Predicted to enable RNA endonuclease activity. Predicted to be involved in RNA catabolic process. Predicted to be located in endoplasmic reticulum lumen; extracellular space; and lysosome. Predicted to be active in extracellular region. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; RNASET2-deficient cystic leukoencephalopathy; colorectal cancer (multiple); lung cancer; and mismatch repair cancer syndrome. Orthologous to human RNASET2 (ribonuclease T2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 168.7), adrenal adult (RPKM 135.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnaset2a in Genome Data Viewer
Location:
17 A1; 17 4.87 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (8347412..8367078, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (8128580..8148246, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1604A Neighboring gene predicted gene, 22416 Neighboring gene STARR-seq mESC enhancer starr_41760 Neighboring gene predicted gene, 41523 Neighboring gene STARR-positive B cell enhancer mm9_chr17:8358162-8358463 Neighboring gene STARR-positive B cell enhancer ABC_E7487 Neighboring gene centrosomal protein 43 Neighboring gene STARR-seq mESC enhancer starr_41762 Neighboring gene C-C motif chemokine receptor 6 Neighboring gene predicted gene, 33799

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy. Kettwig M, et al. Nat Commun, 2021 Nov 11. PMID 34764281, Free PMC Article
  2. Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies. Trubia M, et al. Genomics, 1997 Jun 1. PMID 9192857
  3. Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis. Zhang T, et al. Cell Signal, 2023 Nov. PMID 37633478
  4. An analysis of expression patterns of genes encoding proteins with catalytic activities. Cankaya M, et al. BMC Genomics, 2007 Jul 12. PMID 17626619, Free PMC Article
  5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis.
    Title: Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC27782, MGC107248

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA nuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables ribonuclease T2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal lumen IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribonuclease T2-A
Names
ribonuclease 6
ribonuclease 6-A
ribonuclease T2
NP_001077407.1
NP_001351881.1
NP_001351882.1
NP_001351883.1
XP_006523338.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083938.3 → NP_001077407.1  ribonuclease T2-A isoform 1 precursor

    See identical proteins and their annotated locations for NP_001077407.1

    Status: VALIDATED

    Source sequence(s)
    AK018722, CJ214477
    Consensus CDS
    CCDS37433.1
    UniProtKB/Swiss-Prot
    C0HKG5, C0HKG6, Q9CQ01
    UniProtKB/TrEMBL
    Q5FWA0
    Related
    ENSMUSP00000095031.6, ENSMUST00000097420.7
    Conserved Domains (1) summary
    cd01061
    Location:39 → 221
    RNase_T2_euk; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...

  2. NM_001364952.1 → NP_001351881.1  ribonuclease T2-A isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164314, AC168980
    Conserved Domains (1) summary
    cl00208
    Location:39 → 184
    RNase_T2; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...

  3. NM_001364953.1 → NP_001351882.1  ribonuclease T2-A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC164314, AC168980
    UniProtKB/TrEMBL
    A0A338P711
    Conserved Domains (1) summary
    pfam00445
    Location:2 → 127
    Ribonuclease_T2; Ribonuclease T2 family

  4. NM_001364954.1 → NP_001351883.1  ribonuclease T2-A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC164314, AC168980
    UniProtKB/TrEMBL
    A0A338P711, A0A338P7E3
    Conserved Domains (1) summary
    cl00208
    Location:1 → 125
    RNase_T2; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    8347412..8367078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523275.3 → XP_006523338.1  ribonuclease T2-A isoform X1

    UniProtKB/TrEMBL
    A0A338P711
    Conserved Domains (1) summary
    pfam00445
    Location:2 → 127
    Ribonuclease_T2; Ribonuclease T2 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C0HKG5.1 GenPept UniProtKB/Swiss-Prot:C0HKG5

Gene LinkOut

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Chemical Information
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Research Materials
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