Rsph3b radial spoke 3B homolog (Chlamydomonas) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rsph3bprovided by MGI
Official Full Name: radial spoke 3B homolog (Chlamydomonas)provided by MGI
Primary source: MGI:MGI:3630308
See related: Ensembl:ENSMUSG00000023806 AllianceGenome:MGI:3630308
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rshl2b
Summary: Predicted to be involved in epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and mating. Located in 9+2 motile cilium and axoneme. Part of radial spoke head 1 and radial spoke head 3. Is expressed in choroid invagination; diencephalon roof plate; and metencephalon part of 4th ventricle choroid plexus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 32. Orthologous to human RSPH3 (radial spoke head 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 176.0), ovary adult (RPKM 32.1) and 22 other tissues See more
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Genomic context

Location:: 17 A1; 17 4.51 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (7172115..7215755, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (6904716..6948356, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that RSP3 is a nucleocytoplasmic shuttling protein and plays an essential role in neurogenesis.
Title: The mouse radial spoke protein 3 is a nucleocytoplasmic shuttling protein that promotes neurogenesis.
The subcellular localization and function of mammalian RSP3 in mammalian cells and developing CNS.
Title: Subcellular localization and function of mouse radial spoke protein 3 in mammalian cells and central nervous system.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rshl2a (e-PCR), detects polymorphism
- UniSTS:498253

RH125119 (e-PCR)
- UniSTS:161941

NoName (e-PCR)
- UniSTS:491464

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in epithelial cilium movement involved in extracellular fluid movement	IC Inferred by Curator more info	PubMed
involved_in flagellated sperm motility	IC Inferred by Curator more info	PubMed
involved_in mating	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in 9+2 motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of radial spoke head	IDA Inferred from Direct Assay more info	PubMed
part_of radial spoke head 1	IDA Inferred from Direct Assay more info	PubMed
part_of radial spoke head 3	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: radial spoke head protein 3 homolog B

Names: A-kinase anchor protein RSPH3B; radial spoke head-like protein 2B; radial spokehead-like 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.