hs3st3l heparan sulfate (glucosamine) 3-O-sulfotransferase 3-like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hs3st3lprovided by ZNC
Official Full Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 3-likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070202-6
See related: Ensembl:ENSDARG00000059903 AllianceGenome:ZFIN:ZDB-GENE-070202-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: 3OST6; HS3st6; 3-OST-6
Summary: Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Acts upstream of or within cilium assembly; cilium movement; and symbiont entry into host cell. Predicted to be located in membrane. Is expressed in brain; hindbrain; and neural tube. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (415804..431149, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (409863..425208, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

two members of the 3-OST family are required in distinct signaling pathways to control left-right (LR) patterning through control of Kupffer's vesicle (KV) cilia length and motility.
Title: Differential roles for 3-OSTs in the regulation of cilia length and motility.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within symbiont entry into host cell	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heparan sulfate (glucosamine) 3-O-sulfotransferase 3-like

Names: heparan sulfate 3-O-sulfotransferase 6; zf3-ost-6

NP_001074909.1

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.