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adnp2a ADNP homeobox 2a [ Danio rerio (zebrafish) ]

Gene ID: 100007394, updated on 9-Dec-2024

Summary

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Official Symbol
adnp2aprovided by ZNC
Official Full Name
ADNP homeobox 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040914-55
See related
Ensembl:ENSDARG00000060937 AllianceGenome:ZFIN:ZDB-GENE-040914-55
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
adnp2; znf508; im:6912290; wu:fc45g06
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Acts upstream of or within erythrocyte maturation. Predicted to be active in nucleus. Orthologous to human ADNP2 (ADNP homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See adnp2a in Genome Data Viewer
Location:
chromosome: 16
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (25373723..25380902, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (25458691..25465870, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zinc finger and AT hook domain containing Neighboring gene ribosome binding factor A Neighboring gene par-6 family cell polarity regulator gamma a Neighboring gene zgc:136493

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Novel evolutionary-conserved role for the activity-dependent neuroprotective protein (ADNP) family that is important for erythropoiesis. Dresner E, et al. J Biol Chem, 2012 Nov 23. PMID 23071114, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within erythrocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
activity-dependent neuroprotective protein 2a
Names
ADNP homeobox 2
ADNP homeobox protein 2a
activity-dependent neuroprotector homeobox protein 2a
zinc finger protein 508

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098265.1 → NP_001091735.1  activity-dependent neuroprotective protein 2a

    See identical proteins and their annotated locations for NP_001091735.1

    Status: PROVISIONAL

    Source sequence(s)
    BC139614
    UniProtKB/Swiss-Prot
    A4QP16, F1QAC9
    Related
    ENSDARP00000080810.4, ENSDART00000086375.5
    Conserved Domains (3) summary
    smart00389
    Location:800 → 843
    HOX; Homeodomain
    pfam12756
    Location:551 → 674
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam15752
    Location:327 → 428
    DUF4688; Domain of unknown function (DUF4688)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    25373723..25380902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4QP16.1 GenPept UniProtKB/Swiss-Prot:A4QP16

Gene LinkOut

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