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a2ml3 alpha-2-macroglobulin-like 3 [ Danio rerio (zebrafish) ]

Gene ID: 100006947, updated on 9-Dec-2024

Summary

Official Symbol
a2ml3provided by ZNC
Official Full Name
alpha-2-macroglobulin-like 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9800
See related
Ensembl:ENSDARG00000041645 AllianceGenome:ZFIN:ZDB-GENE-030131-9800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb37; im:7000403; wu:fb66f01
Summary
Is expressed in yolk syncytial layer. Orthologous to human PZP (PZP alpha-2-macroglobulin like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See a2ml3 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (21137046..21155652, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (21201314..21219932, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene alpha-2-macroglobulin-like 2 Neighboring gene alpha-2-macroglobulin-like Neighboring gene alpha-2-macroglobulin Neighboring gene alpha-2-macroglobulin-like Neighboring gene alpha-2-macroglobulin

Genomic regions, transcripts, and products

General gene information

Markers

General protein information

Preferred Names
alpha-2-macroglobulin
Names
a2m

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386282.1NP_001373211.1  alpha-2-macroglobulin precursor

    Status: VALIDATED

    Source sequence(s)
    CR626907
    UniProtKB/TrEMBL
    A0A8M1PVD2
    Related
    ENSDARP00000046442.6, ENSDART00000046443.7
    Conserved Domains (5) summary
    COG2373
    Location:1281430
    YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    cd02897
    Location:9481234
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:729817
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:13411431
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:459609
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    21137046..21155652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)