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stim1b stromal interaction molecule 1b [ Danio rerio (zebrafish) ]

Gene ID: 100005700, updated on 9-Dec-2024

Summary

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Official Symbol
stim1bprovided by ZNC
Official Full Name
stromal interaction molecule 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060531-4
See related
Ensembl:ENSDARG00000061560 AllianceGenome:ZFIN:ZDB-GENE-060531-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
stim1; si:ch211-112l17.2
Summary
Predicted to enable calcium channel regulator activity and calcium ion binding activity. Predicted to be involved in intracellular calcium ion homeostasis and store-operated calcium entry. Predicted to act upstream of or within calcium ion transport. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including brain; head; liver; pleuroperitoneal region; and skeletal muscle. Human ortholog(s) of this gene implicated in Stormorken syndrome; gastrointestinal system cancer (multiple); immunodeficiency 10; lung cancer; and tubular aggregate myopathy 1. Orthologous to human STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See stim1b in Genome Data Viewer
Location:
chromosome: 21
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (30838266..30935194, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (30803984..30898615, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488830 Neighboring gene ribonucleotide reductase M1 polypeptide Neighboring gene solute carrier family 6 member 7 Neighboring gene uncharacterized LOC101886778 Neighboring gene ras homolog family member Gb Neighboring gene post-GPI attachment to proteins 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. SOCE proteins, STIM1 and Orai1, are localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos. Chan CM, et al. Zygote, 2016 Dec. PMID 27702423
  2. STIM1 activation of adenylyl cyclase 6 connects Ca(2+) and cAMP signaling during melanogenesis. Motiani RK, et al. EMBO J, 2018 Mar 1. PMID 29311116, Free PMC Article
  3. Identification of Zebrafish Calcium Toolkit Genes and their Expression in the Brain. Wasilewska I, et al. Genes (Basel), 2019 Mar 18. PMID 30889933, Free PMC Article
  4. Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae. Gupta RK, et al. Int J Mol Sci, 2020 Aug 27. PMID 32867296, Free PMC Article
  5. Identification of Ca(2+) signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres. Tse MK, et al. Sci China Life Sci, 2018 Nov. PMID 29931586

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the Endoplasmic reticulum calcium sensor protein STIM1 (stromal interaction molecule 1) interacts with the plasma membrane-localized adenylyl cyclase 6 (ADCY6) to govern melanogenesis.
    Title: STIM1 activation of adenylyl cyclase 6 connects Ca(2+) and cAMP signaling during melanogenesis.
  2. STIM1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
    Title: SOCE proteins, STIM1 and Orai1, are localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transport IEA
Inferred from Electronic Annotation
more info
  
involved_in store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
stromal interaction molecule 1b
Names
stromal interaction molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202541.1 → NP_001189470.1  stromal interaction molecule 1b precursor

    Status: VALIDATED

    Source sequence(s)
    BX511168, BX936320
    UniProtKB/TrEMBL
    A0A8M1P2M0
    Conserved Domains (4) summary
    smart00454
    Location:123 → 187
    SAM; Sterile alpha motif
    pfam04880
    Location:251 → 333
    NUDE_C; NUDE protein, C-terminal conserved region
    pfam16533
    Location:338 → 435
    SOAR; STIM1 Orai1-activating region
    cl15755
    Location:122 → 195
    SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    30838266..30935194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009295557.4 → XP_009293832.1  stromal interaction molecule 1b isoform X2

    UniProtKB/TrEMBL
    A0A8M3AU34, F1R6G6
    Related
    ENSDARP00000121917.1, ENSDART00000142079.3
    Conserved Domains (4) summary
    smart00454
    Location:123 → 187
    SAM; Sterile alpha motif
    pfam04880
    Location:250 → 332
    NUDE_C; NUDE protein, C-terminal conserved region
    pfam16533
    Location:337 → 434
    SOAR; STIM1 Orai1-activating region
    cl15755
    Location:122 → 195
    SAM_superfamily; SAM (Sterile alpha motif )

  2. XM_005161288.5 → XP_005161345.1  stromal interaction molecule 1b isoform X1

    UniProtKB/TrEMBL
    A0A0R4IAT9, A0A8M2B879
    Related
    ENSDARP00000131780.1, ENSDART00000172390.2
    Conserved Domains (4) summary
    smart00454
    Location:123 → 187
    SAM; Sterile alpha motif
    pfam04880
    Location:250 → 332
    NUDE_C; NUDE protein, C-terminal conserved region
    pfam16533
    Location:337 → 434
    SOAR; STIM1 Orai1-activating region
    cl15755
    Location:122 → 195
    SAM_superfamily; SAM (Sterile alpha motif )
Nucleotide Protein
Heading Accession and Version

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