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greb1l GREB1 like retinoic acid receptor coactivator [ Danio rerio (zebrafish) ]

Gene ID: 100005373, updated on 9-Dec-2024

Summary

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Official Symbol
greb1lprovided by ZNC
Official Full Name
GREB1 like retinoic acid receptor coactivatorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4022
See related
Ensembl:ENSDARG00000039196 AllianceGenome:ZFIN:ZDB-GENE-030131-4022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc65f09; wu:fc55e03; wu:fc65f09; si:dkey-203o21.1; si:dkey-264l15.1
Summary
Involved in kidney development. Acts upstream of or within pronephros development. Predicted to be located in membrane. Is expressed in central nervous system and mesoderm. Used to study renal agenesis. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and renal agenesis. Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See greb1l in Genome Data Viewer
Location:
chromosome: 2
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (11685808..11833278)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (11902197..12049680)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene mitochondrial fission factor b Neighboring gene finTRIM family, member 1 Neighboring gene abhydrolase domain containing 3, phospholipase Neighboring gene Ro60, Y RNA binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Gene Implicated in Activation of Retinoic Acid Receptor Targets Is a Novel Renal Agenesis Gene in Humans. Brophy PD, et al. Genetics, 2017 Sep. PMID 28739660, Free PMC Article
  2. Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations. Sanna-Cherchi S, et al. Am J Hum Genet, 2017 Nov 2. PMID 29100090, Free PMC Article
  3. SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish. Liang F, et al. Nat Commun, 2022 Jun 14. PMID 35701400, Free PMC Article
  4. Transcriptional profiling of angiogenesis activities of calycosin in zebrafish. Li S, et al. Mol Biosyst, 2011 Nov. PMID 21909574
  5. Genomewide expression profiling in the zebrafish embryo identifies target genes regulated by Hedgehog signaling during vertebrate development. Xu J, et al. Genetics, 2006 Oct. PMID 16888327, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • KIAA0575

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in kidney development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of an epithelium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pronephros development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GREB1-like protein
Names
growth regulation by estrogen in breast cancer-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362307.1 → NP_001349236.1  GREB1-like protein

    Status: VALIDATED

    Source sequence(s)
    CT573467, CU138514, CU682364
    UniProtKB/Swiss-Prot
    B8JKP6, F1QLH8
    UniProtKB/TrEMBL
    A0A8M9NZP6
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1942
    GREB1; Gene regulated by oestrogen in breast cancer

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    11685808..11833278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009298040.3 → XP_009296315.1  GREB1-like protein isoform X1

    See identical proteins and their annotated locations for XP_009296315.1

    UniProtKB/Swiss-Prot
    B8JKP6, F1QLH8
    UniProtKB/TrEMBL
    A0A8M9NZP6
    Related
    ENSDARP00000122959.2, ENSDART00000138562.4
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1942
    GREB1; Gene regulated by oestrogen in breast cancer

  2. XM_068222368.1 → XP_068078469.1  GREB1-like protein isoform X1

    UniProtKB/Swiss-Prot
    B8JKP6, F1QLH8
    UniProtKB/TrEMBL
    A0A8M9NZP6

  3. XM_021466912.2 → XP_021322587.1  GREB1-like protein isoform X1

    UniProtKB/Swiss-Prot
    B8JKP6, F1QLH8
    UniProtKB/TrEMBL
    A0A8M9NZP6
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1942
    GREB1; Gene regulated by oestrogen in breast cancer
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B8JKP6.2 GenPept UniProtKB/Swiss-Prot:B8JKP6

Gene LinkOut

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