depdc1a DEP domain containing 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: depdc1aprovided by ZNC
Official Full Name: DEP domain containing 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9827
See related: Ensembl:ENSDARG00000018165 AllianceGenome:ZFIN:ZDB-GENE-030131-9827
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb41; depdc1; sb:cb41; zgc:55374; wu:fc05g03
Summary: Predicted to enable GTPase activator activity. Predicted to act upstream of or within intracellular signal transduction. Is expressed in nervous system; pectoral fin musculature; pharyngeal arch 3-7 skeleton; and proliferative region. Orthologous to human DEPDC1 (DEP domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (16712813..16725573, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (16677103..16689866, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi22d05.x1 (e-PCR)
- UniSTS:197042

fc05g03.x1 (e-PCR)
- UniSTS:203713

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DEP domain-containing protein 1A

Names: DEP domain containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198872.2 → NP_942573.2 DEP domain-containing protein 1A

Status: VALIDATED

Source sequence(s)

CR759968

UniProtKB/Swiss-Prot

Q803Q4

Related

ENSDARP00000049675.7, ENSDART00000049676.8

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

16712813..16725573 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166773.4 → XP_005166830.1 DEP domain-containing protein 1A isoform X1

UniProtKB/TrEMBL

A0A2R8QHF9, A0A8M2BEB0

Related

ENSDARP00000152474.1, ENSDART00000183593.1

Conserved Domains (2) summary

cd04405
Location:174 → 398

RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...

cd04447
Location:15 → 106

DEP_BRCC3; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function.