adgra3 adhesion G protein-coupled receptor A3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adgra3provided by ZNC
Official Full Name: adhesion G protein-coupled receptor A3provided by ZNC
Primary source: ZFIN:ZDB-GENE-131003-2
See related: AllianceGenome:ZFIN:ZDB-GENE-131003-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gpr125
Summary: Predicted to enable G protein-coupled receptor activity. Acts upstream of or within several processes, including Wnt signaling pathway, planar cell polarity pathway; motor neuron migration; and regulation of Wnt signaling pathway, planar cell polarity pathway. Located in plasma membrane. Is expressed in several structures, including brain; liver; otic vesicle; pectoral fin; and pleuroperitoneal region. Orthologous to human ADGRA3 (adhesion G protein-coupled receptor A3). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 7

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (70267090..70333181, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (69816793..69882884, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identified Gpr125, an adhesion G protein-coupled receptor, as a novel modulator of the Wnt/PCP signaling system. Excess Gpr125 impaired convergence and extension movements and the underlying cell and molecular polarities.
Title: Gpr125 modulates Dishevelled distribution and planar cell polarity signaling.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within convergent extension involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within motor neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of Wnt signaling pathway, planar cell polarity pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of Wnt signaling pathway, planar cell polarity pathway	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: adhesion G protein-coupled receptor A3

Names: G-protein coupled receptor 125

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302224.1 → NP_001289153.1 adhesion G protein-coupled receptor A3 precursor

See identical proteins and their annotated locations for NP_001289153.1

Status: PROVISIONAL

Source sequence(s)

KC996731

UniProtKB/Swiss-Prot

S4X0Q8

Conserved Domains (10) summary

smart00082
Location:176 → 223

LRRCT; Leucine rich repeat C-terminal domain

smart00410
Location:236 → 328

IG_like; Immunoglobulin like

cd00116
Location:73 → 162

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:70 → 93

LRR_1; leucine-rich repeat [structural motif]

pfam01825
Location:680 → 721

GPS; GPCR proteolysis site, GPS, motif

pfam02793
Location:350 → 403

HRM; Hormone receptor domain

pfam13855
Location:92 → 152

LRR_8; Leucine rich repeat

pfam16489
Location:424 → 648

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl11960
Location:241 → 324

Ig; Immunoglobulin domain

cl21561
Location:774 → 923

7tm_4; Olfactory receptor