herc3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: herc3provided by ZNC
Official Full Name: HECT and RLD domain containing E3 ubiquitin protein ligase 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-090313-139
See related: Ensembl:ENSDARG00000075887 AllianceGenome:ZFIN:ZDB-GENE-090313-139
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch73-190m4.3
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Orthologous to human HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (50639416..50691538)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (49995590..50047712)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable E3 ubiquitin-protein ligase HERC3

Names: hect domain and RLD 3

NP_001139096.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145624.1 → NP_001139096.1 probable E3 ubiquitin-protein ligase HERC3

Status: PROVISIONAL

Source sequence(s)

CU467858

UniProtKB/TrEMBL

A0A8M1NTA5, B8JLD4

Related

ENSDARP00000123243.1, ENSDART00000141977.2

Conserved Domains (4) summary

smart00119
Location:723 → 1043

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:699 → 1044

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00415
Location:208 → 257

RCC1; Regulator of chromosome condensation (RCC1) repeat

pfam13540
Location:37 → 65

RCC1_2; Regulator of chromosome condensation (RCC1) repeat