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man2b2 mannosidase, alpha, class 2B, member 2 [ Danio rerio (zebrafish) ]

Gene ID: 100003570, updated on 9-Dec-2024

Summary

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Official Symbol
man2b2provided by ZNC
Official Full Name
mannosidase, alpha, class 2B, member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-140106-166
See related
Ensembl:ENSDARG00000079463 AllianceGenome:ZFIN:ZDB-GENE-140106-166
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable alpha-mannosidase activity; carbohydrate binding activity; and metal ion binding activity. Predicted to act upstream of or within mannose metabolic process. Orthologous to human MAN2B2 (mannosidase alpha class 2B member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See man2b2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (19509889..19526733, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (19257947..19274765, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:ch211-212k18.8 Neighboring gene si:ch211-212k18.9 Neighboring gene tetratricopeptide repeat domain 5 Neighboring gene cyclin B1 interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Liver toxicity of macrolide antibiotics in zebrafish. Zhang MQ, et al. Toxicology, 2020 Aug. PMID 32454074
  2. eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs. Lorenzo-Orts L, et al. EMBO Rep, 2024 Jan. PMID 38177902, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
epididymis-specific alpha-mannosidase
Names
zmp:0000001206
XP_001337519.3
XP_021333425.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    19509889..19526733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477750.2 → XP_021333425.1  epididymis-specific alpha-mannosidase

    UniProtKB/TrEMBL
    A0A8M1PZ41, A0A8M6Z1P3, E7F2X1
    Related
    ENSDARP00000099510.2, ENSDART00000114203.5
    Conserved Domains (2) summary
    PLN02701
    Location:20 → 1002
    PLN02701; alpha-mannosidase
    cl25404
    Location:23 → 348
    GH38-57_N_LamB_YdjC_SF; Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394683.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    232096..248940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001337483.7 → XP_001337519.3  epididymis-specific alpha-mannosidase

    UniProtKB/TrEMBL
    A0A8M1PZ41, A0A8M6Z1P3, E7F2X1
    Conserved Domains (2) summary
    PLN02701
    Location:20 → 1002
    PLN02701; alpha-mannosidase
    cl25404
    Location:23 → 348
    GH38-57_N_LamB_YdjC_SF; Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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