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pprc1 PPARG related coactivator 1 [ Danio rerio (zebrafish) ]

Gene ID: 100002463, updated on 4-Jan-2025

Summary

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Official Symbol
pprc1provided by ZNC
Official Full Name
PPARG related coactivator 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9858
See related
Ensembl:ENSDARG00000090337 AllianceGenome:ZFIN:ZDB-GENE-030131-9858
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb478; sb:cb478; wu:fb72d09; wu:fj86g08
Summary
Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in energy homeostasis and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; anterior axial hypoblast; brain; immature eye; and mesoderm. Orthologous to human PPRC1 (PPARG related coactivator 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See pprc1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (12007904..12021510, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (11875436..11889035, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene nucleophosmin/nucleoplasmin, 3 Neighboring gene O-GlcNAcase Neighboring gene guanine nucleotide binding protein (G protein), gamma 2 Neighboring gene uncharacterized LOC137487211 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Temperature during embryonic development has persistent effects on thermal acclimation capacity in zebrafish. Scott GR, et al. Proc Natl Acad Sci U S A, 2012 Aug 28. PMID 22891320, Free PMC Article
  2. Metabolic regulation by the PGC-1α and PGC-1β coactivators in larval zebrafish (Danio rerio). Northam C, et al. Comp Biochem Physiol A Mol Integr Physiol, 2019 Aug. PMID 31004809
  3. Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting. Gu Q, et al. Hepatology, 2014 Dec. PMID 25130427
  4. Bone morphogenetic protein signaling governs biliary-driven liver regeneration in zebrafish through tbx2b and id2a. Choi TY, et al. Hepatology, 2017 Nov. PMID 28599080, Free PMC Article
  5. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in energy homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Names
peroxisome proliferator-activated receptor gamma, coactivator-related 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    12007904..12021510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001338200.8 → XP_001338236.3  peroxisome proliferator-activated receptor gamma coactivator-related protein 1

    UniProtKB/TrEMBL
    A0A8M1PZ78, E7F4W0
    Related
    ENSDARP00000107880.1, ENSDART00000125430.3
    Conserved Domains (1) summary
    cl17169
    Location:1098 → 1188
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version

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