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marchf6 membrane-associated ring finger (C3HC4) 6 [ Danio rerio (zebrafish) ]

Gene ID: 100002072, updated on 9-Dec-2024

Summary

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Official Symbol
marchf6provided by ZNC
Official Full Name
membrane-associated ring finger (C3HC4) 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-530
See related
Ensembl:ENSDARG00000076066 AllianceGenome:ZFIN:ZDB-GENE-070912-530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
march6; fa98a02; im:7161807; wu:fa98a02; si:dkey-40c17.2
Summary
Predicted to enable transferase activity and zinc ion binding activity. Predicted to be involved in ERAD pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 3. Orthologous to human MARCHF6 (membrane associated ring-CH-type finger 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See marchf6 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (30489838..30527330)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (30506267..30543797)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487883 Neighboring gene fATP synthase c subunit lysine N-methyltransferase Neighboring gene ankyrin repeat domain 33Bb Neighboring gene catenin (cadherin-associated protein), delta 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish MARCH7 negatively regulates IFN antiviral response by degrading TBK1. Xiong ST, et al. Int J Biol Macromol, 2023 Jun 15. PMID 37054851
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MARCHF6
NP_001278636.1
XP_003197917.1
XP_005163506.1
XP_005163507.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291707.1 → NP_001278636.1  E3 ubiquitin-protein ligase MARCHF6

    Status: VALIDATED

    Source sequence(s)
    CK024583, CR388419, CT661348, EB899125, EB935699, EB949406, EH451889
    UniProtKB/TrEMBL
    A0A8M1P6Q7, E9QDQ9
    Related
    ENSDARP00000117758.1, ENSDART00000145732.3
    Conserved Domains (1) summary
    smart00744
    Location:9 → 57
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    30489838..30527330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163449.5 → XP_005163506.1  E3 ubiquitin-protein ligase MARCHF6 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BAR2
    Conserved Domains (1) summary
    smart00744
    Location:9 → 57
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  2. XM_005163450.5 → XP_005163507.1  E3 ubiquitin-protein ligase MARCHF6 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BAJ3
    Conserved Domains (1) summary
    smart00744
    Location:9 → 57
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  3. XM_003197869.6 → XP_003197917.1  E3 ubiquitin-protein ligase MARCHF6 isoform X2

    UniProtKB/TrEMBL
    A0A8M1RN76
    Conserved Domains (1) summary
    smart00744
    Location:9 → 57
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
Nucleotide Protein Strain
Heading Accession and Version

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