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tfcp2 transcription factor CP2 [ Danio rerio (zebrafish) ]

Gene ID: 100001906, updated on 4-Jan-2025

Summary

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Official Symbol
tfcp2provided by ZNC
Official Full Name
transcription factor CP2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2523
See related
Ensembl:ENSDARG00000060306 AllianceGenome:ZFIN:ZDB-GENE-030131-2523
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc10e04; wu:fc10e04; si:ch211-210c8.8
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain. Orthologous to human TFCP2 (transcription factor CP2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See tfcp2 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (33657005..33680265, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (33730474..33753751, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489140 Neighboring gene cysteine-serine-rich nuclear protein 2 Neighboring gene POU class 6 homeobox 1 Neighboring gene DAZ associated protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish grainyhead-like1 is a common marker of different non-keratinocyte epidermal cell lineages, which segregate from each other in a Foxi3-dependent manner. Janicke M, et al. Int J Dev Biol, 2010. PMID 19757382, Free PMC Article
  2. Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Ahi EP, et al. Fish Physiol Biochem, 2021 Aug. PMID 34236575, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-globin transcription factor CP2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    33657005..33680265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017353731.3 → XP_017209220.1  alpha-globin transcription factor CP2 isoform X4

    UniProtKB/TrEMBL
    A0A8M6YW24

  2. XM_005162355.5 → XP_005162412.1  alpha-globin transcription factor CP2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B984
    Conserved Domains (2) summary
    cd09589
    Location:343 → 409
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:57 → 257
    CP2; CP2 transcription factor

  3. XM_001336446.7 → XP_001336482.2  alpha-globin transcription factor CP2 isoform X3

    UniProtKB/TrEMBL
    A0A8M1Q1I0
    Conserved Domains (2) summary
    cd09589
    Location:331 → 397
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:57 → 257
    CP2; CP2 transcription factor

  4. XM_005162354.5 → XP_005162411.1  alpha-globin transcription factor CP2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B9A0, E7EYC1
    Related
    ENSDARP00000121618.1, ENSDART00000138416.2
    Conserved Domains (2) summary
    cd09589
    Location:345 → 411
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:57 → 257
    CP2; CP2 transcription factor
Nucleotide Protein Strain
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