ttn.1 titin, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ttn.1provided by ZNC
Official Full Name: titin, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-413
See related: Ensembl:ENSDARG00000000563 AllianceGenome:ZFIN:ZDB-GENE-030616-413
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: TTN; ttnb; ttnl; im:6911926; im:7146708; wu:fc09a12; hm:zeh1256r; si:dZ167C3.1; si:dz249n21.1
Summary: Predicted to be a structural constituent of muscle. Acts upstream of or within myofibril assembly and skeletal muscle tissue development. Predicted to be active in M band. Is expressed in several structures, including cardiovascular system; floor plate; mesoderm; musculature system; and pectoral fin. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to human TTN (titin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 214

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (42732992..42873875, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (42931208..43072073, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Digenic inheritance involving a muscle-specific protein kinase and the giant titin protein causes a skeletal muscle myopathy.
Title: Digenic inheritance involving a muscle-specific protein kinase and the giant titin protein causes a skeletal muscle myopathy.
Heterozygosity for A-band titin truncation is sufficient to cause Dilated cardiomyopathy in adult zebrafish. Abnormalities of systolic and diastolic reserve in titin-truncated fish reduce stress tolerance and may contribute to a substrate for atrial arrhythmogenesis.
Title: A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance.
The data support a mechanism of Hsp27 function where interactions with the titin filament system protect myofibrils from stress-induced degradation.
Title: Hsp27 associates with the titin filament system in heat-shocked zebrafish cardiomyocytes.
This study reports linkage of the runzel homozygous lethal muscular dystrophy in the zebrafish Danio rerio to a genomic interval containing the titin gene.
Title: The zebrafish runzel muscular dystrophy is linked to the titin gene.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fc52g09.y1 (e-PCR)
- UniSTS:194052

AI588106 (e-PCR)
- UniSTS:206206

fb96b11 (e-PCR), detects polymorphism
- UniSTS:189107

fc09a12.x1 (e-PCR)
- UniSTS:203768

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within myofibril assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sarcomerogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sarcomerogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within striated muscle myosin thick filament assembly	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: titin; titin b

Names: TTN1; connectin b

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

42732992..42873875 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068223495.1 → XP_068079596.1 titin

UniProtKB/TrEMBL

A0A8M9QGA6

Related

ENSDARP00000107866.3, ENSDART00000125953.4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_207183.1: Suppressed sequence

Description

NM_207183.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.