gpr137ba G protein-coupled receptor 137Ba [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gpr137baprovided by ZNC
Official Full Name: G protein-coupled receptor 137Baprovided by ZNC
Primary source: ZFIN:ZDB-GENE-100721-1
See related: Ensembl:ENSDARG00000078448 AllianceGenome:ZFIN:ZDB-GENE-100721-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Involved in negative regulation of bone resorption; negative regulation of osteoclast differentiation; and regulation of autophagy. Acts upstream of or within bone remodeling and regulation of lysosome size. Predicted to be located in lysosome and membrane. Predicted to be active in lysosomal membrane. Is expressed in female organism. Orthologous to human GPR137B (G protein-coupled receptor 137B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (50151621..50495591)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (49838510..49855662)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish.
Title: A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of bone resorption	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of osteoclast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein localization to lysosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of lysosome size	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G protein-coupled receptor 137Ba

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.