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glula glutamate-ammonia ligase (glutamine synthase) a [ Danio rerio (zebrafish) ]

Gene ID: 100000775, updated on 12-Jan-2025

Summary

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Official Symbol
glulaprovided by ZNC
Official Full Name
glutamate-ammonia ligase (glutamine synthase) aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-688
See related
Ensembl:ENSDARG00000099776 AllianceGenome:ZFIN:ZDB-GENE-030131-688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gso1; cb195; cb757; fb39g09; fd19d09; sb:cb195; wu:fb39g09; wu:fd19d09; etID49849.2
Summary
Predicted to enable glutamine synthetase activity. Predicted to be involved in glutamine biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic system; musculature system; and nervous system. Human ortholog(s) of this gene implicated in congenital glutamine deficiency; epilepsy (multiple); heart disease; and neurodegenerative disease (multiple). Orthologous to human GLUL (glutamate-ammonia ligase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See glula in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (18988410..18992347)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (19339346..19343283)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487787 Neighboring gene uncharacterized LOC137487790 Neighboring gene pre-B-cell leukemia homeobox 1a Neighboring gene transmembrane protein 275a Neighboring gene kinocilin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Elovl2 Is Required for Robust Visual Function in Zebrafish. Dasyani M, et al. Cells, 2020 Dec 2. PMID 33276584, Free PMC Article
  2. Glutamine synthetase activity and the expression of three glul paralogues in zebrafish during transport. Dhanasiri AK, et al. Comp Biochem Physiol B Biochem Mol Biol, 2012 Nov-Dec. PMID 22750401
  3. A Zebrafish Model of Retinitis Pigmentosa Shows Continuous Degeneration and Regeneration of Rod Photoreceptors. Santhanam A, et al. Cells, 2020 Oct 6. PMID 33036185, Free PMC Article
  4. Differential Apoptotic and Mitogenic Effects of Lectins in Zebrafish. Wang K, et al. Front Endocrinol (Lausanne), 2019. PMID 31231312, Free PMC Article
  5. LIM Homeobox 9 knockdown by morpholino does not affect zebrafish retinal development. Guo R, et al. Biol Open, 2021 Mar 8. PMID 33579692, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC63917

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamine synthetase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamine synthetase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glutamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamate-ammonia ligase (glutamine synthase) a
Names
glutamine synthetase 1
gs
NP_853537.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181559.2 → NP_853537.1  glutamate-ammonia ligase (glutamine synthase) a

    See identical proteins and their annotated locations for NP_853537.1

    Status: VALIDATED

    Source sequence(s)
    BC171369, EH438060, EH462514
    UniProtKB/TrEMBL
    B7ZUV7, Q7T2P7
    Related
    ENSDARP00000134084.1, ENSDART00000170216.2
    Conserved Domains (3) summary
    PLN02284
    Location:22 → 362
    PLN02284; glutamine synthetase
    pfam00120
    Location:128 → 356
    Gln-synt_C; Glutamine synthetase, catalytic domain
    pfam03951
    Location:30 → 104
    Gln-synt_N; Glutamine synthetase, beta-Grasp domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    18988410..18992347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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