GEO DataSets

(Submitter supplied) Dysregulation of imprinted gene loci also referred to as loss of imprinting (LOI) can result in severe developmental defects and other diseases, but the molecular mechanisms that ensure imprint stability remain incompletely understood. Here, we dissect the functional components of the imprinting control region of the essential Dlk1-Dio3 locus (called IG-DMR) and the mechanism by which they ensure imprinting maintenance. more...

Organism:

Mus musculus; Mus musculus molossinus

Type:

Other

Platform:

GPL28366

12 Samples

Download data: BW

(Submitter supplied) Wild-derived mice have contributed to mouse genetics by their genetic diversity that may increase the chance of identifying novel modifier genes responsible for specific phenotypes and diseases. However, gene-targeting using wild-derived mice has been unsuccessful due to the unavailability of stable embryonic stem cells. Here, we report that the CRISPR/Cas9-mediated gene-targeting can be applied to the Japanese wild-derived MSM/Ms strain. more...

Organism:

Mus musculus molossinus; Mus musculus

Type:

Expression profiling by array

Platform:

GPL21163

8 Samples

Download data: TXT

(Submitter supplied) Here we examine the expression of genes in unstimulated or following intraperitoneal injection with MegaFasL in MSM/Ms and C57BL/6 mouse livers and thymi

Organism:

Mus musculus domesticus; Mus musculus molossinus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL20866 GPL20867

8 Samples

Download data: TXT