GEO DataSets

(Submitter supplied) As vector-borne pathogens transit between the arthropod and vertebrate, adaptation is key for survival as each host varies and initiates unique defense mechanisms. An environmental signal that relapsing fever (RF) and Lyme causing spirochetes detect is the change of temperature between vector and mammal, yet incomplete genomes have hindered progress in understanding the genetic constituents expressed during tick colonization. more...

Organism:

Brucella suis; Borrelia hermsii; Burkholderia mallei; Borrelia turicatae 91E135; Coxiella burnetii; Rickettsia prowazekii; Francisella tularensis

Type:

Expression profiling by array

Platform:

GPL7246

9 Samples

Download data: CEL, CHP

(Submitter supplied) Spirochetes are long, thin, motile, helical or flat wave bacteria that are unique among the prokaryotes by having flagella or axial filaments confined to an internal periplasmic space. These flagella are complex organelles that can play major roles in bacterial pathogenicity and are used as propellers allowing bacteria to move through liquids, viscous environments or along surfaces. While most bacteria species use transcriptional regulatory cascades to regulate the synthesis and assembly of their flagella, spirochetes employ an unusual post-transcriptional mechanism. more...

Organism:

Francisella tularensis; Coxiella burnetii; Rickettsia prowazekii; Burkholderia mallei; Borrelia hermsii; Brucella suis

Type:

Expression profiling by array

Platform:

GPL7246

24 Samples

Download data: CEL, CHP

(Submitter supplied) The highly infectious bacterium Francisella tularensis is a facultative intracellular pathogen, whose virulence requires proliferation inside host cells, including macrophages. Although some Francisella determinants of intracellular growth have been identified, much remains to be understood about the pathogenesis of this organism. In particular, how Francisella responds to its intracellular environment could provide clues about its intracellular biology and reveal pathogenic determinants based on their intracellular expression profiles. more...

Organism:

Francisella tularensis; Coxiella burnetii; Rickettsia prowazekii; Borrelia hermsii; Burkholderia mallei; Francisella tularensis subsp. tularensis SCHU S4; Brucella suis

Type:

Expression profiling by array

Platform:

GPL7246

32 Samples

Download data: CEL, CHP

(Submitter supplied) custom pathogenic Affymetrix chip 2 manufactured for RML Protocol: standard Affymetrix protocol

Organism:

Borrelia hermsii; Francisella tularensis; Coxiella burnetii; Rickettsia prowazekii; Burkholderia mallei; Brucella suis

3 Series

65 Samples

Download data: CDF