GEO DataSets

(Submitter supplied) Chromosome 1p LOH was seen in one-third of cases. LOH events on chromosomes 11q and 1p were generally accompanied by copy number loss. The one exception was on chromosome 11p, where LOH in all 4 cases was accompanied by normal copy number or diploidy, implying uniparental disomy. Amplification of MYCN was also noted, and also, amplification of a second gene, ALK, in a single case. Keywords: SNP array analysis

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platforms:

GPL1266 GPL2641

44 Samples

Download data: CEL, TXT

(Submitter supplied) Lithium has been used for more than 50 years as the primary therapy for bipolar affective disorder (BPD) and is highly effective in its treatment. However, the molecular and cellular mechanisms underlying the lithium’s therapeutic action still remains elusive. The goal of the proposed study is to identify genes involved in the lithium-responsive neurological pathway using the fruit fly as a model organism. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

12 Samples

Download data: CEL

(Submitter supplied) Roux-en-Y gastric bypass (RYGB) is the most effective therapy for morbid obesity, but it has a ~20% failure rate. We used our established RYGB model in diet-induced obese (DIO) Sprague-Dawley rats, which reproduces human bi-phasic body weight (BW) loss pattern, to determine mechanisms contributing to success (RGYB-S) or failed (RYGB-F) RYGB. DIO rats were randomized to RYGB, sham operated Obese, and sham operated obese pair fed-linked to RYGB (PF) groups. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2956

Platform:

GPL1355

18 Samples

Download data: CEL, CHP

(Submitter supplied) In order to dtermine the role of histone actylation in gene expresssion, E. histolytica 200:NIH trophozoites were treated with the HDAC inhibitor Trichostatin A, or grown in short chain fatty acids, which have been shown to alter histone actylation patterns in Entamoeba species. Keywords: Expression

Organism:

Entamoeba histolytica

Type:

Expression profiling by array

Platform:

GPL4622

8 Samples

Download data: CEL

(Submitter supplied) In angiosperms, stigma provides initial nutrients and guidance cues for pollen grain germination and tube growth. However, little is known about genes that regulate these processes in rice. Here we generate rice stigma-specific gene expression profiles through comparing genome-wide expression patterns of hand dissected unpollinated stigma at anthesis with seven tissues including seedling shoot, seedling root, mature anther, ovary at anthesis, seeds of five days after pollination, 10-day-old embryo, 10-day-old endosperm as well as suspension cultured cells by using 57K Affymetrix rice whole genome array. more...

Organism:

Oryza sativa

Type:

Expression profiling by array

Platform:

GPL2025

13 Samples

Download data: CEL

(Submitter supplied) Rationale: Maternal immune responses can promote allergy development in offspring. Pilot data show that neonates of mother mice exposed during pregnancy to air pollution particles have increased allergic susceptibility. Objective: We investigated whether inflammatory response to titanium dioxide (TiO2) particles earlier considered immunologically ‘inert’ is enhanced during pregnancy. Methods: Pregnant BALB/c mice (or non-pregnant controls) received particle suspensions intranasally at day 14 of pregnancy. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2878

Platform:

GPL1261

16 Samples

Download data: CEL, CHP

(Submitter supplied) The small RNAs of Selaginella moellendorffii were sampled by direct pyrosequencing (454 Life Sciences). These data represent microRNAs, siRNAs, and other expressed small RNAs of ~18-~28 nts. in length. Keywords: Small RNA sequencing - high throughput

Organism:

Selaginella moellendorffii

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL5014

1 Sample

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(Submitter supplied) We created mice, which are deficient for Myc specifically in cardiac myocytes by crossing crossed Myc-floxed mice (Mycfl/fl) and MLC-2VCre/+ mice. Serial analysis of earlier stages of gestation revealed that Myc-deficient mice died prematurely at E13.5-14.5. Morphological analyses of E13.5 Myc-null embryos showed normal ventricular size and structure; however, decreased cardiac myocyte proliferation and increased apoptosis was observed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3031

Platform:

GPL4865

7 Samples

Download data: TXT

(Submitter supplied) Gene expression profiling has opened new directions of investigation in scientific research, however, the need for substantial amount of biological material to perform these experiments limits significantly its application range. Here, we have developed procedures to perform microarray analysis on amplified cDNA from single cells, including primary T lymphocytes, and applied this technology to the study of CD4 and CD8 lineage differentiation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL4724 GPL4725 GPL4726

66 Samples

Download data: TXT

(Submitter supplied) The goal of this study was to study the gene expression changes that occurred in BL3 cells that were infected with type 2 bovine viral diarrhea virus (BVDV2). What happens within the cell and how the cell responds to the virus is completely unknown. Keywords: gene expression changes, BVDV2-infected cells, acute infection

Organism:

Bos taurus

Type:

Expression profiling by SAGE

Platform:

GPL223

2 Samples

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(Submitter supplied) Lack of, or abnormal, ovarian follicular development prevents establishment of pregnancy in human and is associated with reduced reproductive efficiency in farm animals. Development of new treatments is limited by our poor understanding of ovarian follicular development. The objective of this study is to identify changes in gene expression during the selection stage of bovine follicular growth. Follicles of different sizes were collected and intrafollicular concentrations of steroids were measured to identify healthy follicles. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL3962

24 Samples

Download data: GPR

(Submitter supplied) gd T cells have an important yet incompletely defined role in inflammation associated with a variety of infectious and autoimmune conditions. To better understand the precise roles of gd T cells relative to ab T cells in a specific infection, we utilized Salmonella Enterica Serovar Typhimurium (S. typhimurium) infection in cattle as it is a leading cause of disease in cattle and closely approximates S. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL2112

18 Samples

Download data

Analysis of Myc-deficient hearts from embryonic day 13.5 transgenics. The E13.5 Myc-null embryos show normal ventricular size and structure, but decreased cardiac myocyte proliferation. Results provide insight into the molecular mechanisms underlying Myc-induced cellular proliferation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL4865

Series:

GSE7162

7 Samples

Download data: TXT

Analysis of subcutaneous abdominal fat and hypothalami of male Sprague-Dawleys that lost or regained weight after Roux-en-Y gastric bypass (RYGB) surgery. Obesity induced by diet prior to RYBG. Results provide insight into the mechanisms contributing to successful weight loss following RYBG.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 disease state, 3 other, 2 protocol, 2 tissue sets

Platform:

GPL1355

Series:

GSE8314

18 Samples

Download data: CEL, CHP

Analysis of lungs from pregnant and non-pregnant BALB/c females following insufflation with inert titanium dioxide particles. Results provide insight into the mechanisms underlying the differences in response between pregnant and non-pregnant females to inhaled inert particles.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 development stage sets

Platform:

GPL1261

Series:

GSE7475

16 Samples

Download data: CEL, CHP

(Submitter supplied) Yeast is a powerful model system for studying the action of small molecule therapeutics. An important limitation has been low efficacy of many small molecules in yeast due to limited intracellular drug accumulation. We used the DNA binding domain of the pleiotropic drug resistance regulator Pdr1 fused in-frame to transcription repressors to repress Pdr1 regulated genes. Expression of these regulators conferred dominant enhancement of drug sensitivity and led to greatly diminished levels of Pdr1p regulated transcripts, including the yeast p-glycoprotein homologue Pdr5. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platform:

GPL90

15 Samples

Download data: CEL

(Submitter supplied) HTI-286, an analogue of hemiasterlin, interferes with microtubule dynamics and circumvents transport-based resistance to taxanes. In this study we evaluate the inhibitory effects of HTI-286 on human prostate cancer growth in vitro and in different in vivo models. The results show that HTI-286 is a potent inhibitor of proliferation and induced marked increases in apoptotic rates in all cell lines tested. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2971

Platform:

GPL3877

12 Samples

Download data

(Submitter supplied) A comparison of "maturing" and "prespawn" ovarian and testicular transciptomes was performed to determine the genes that are involved in regulating gametic and accessory cell function during maturation and development of the rainbow trout gonad. To identify some fo the genes involved in these processee, total RNA was compared between three-year-old normal vs two-year-old normal (maturing) and three-year-old normal vs two-year-old precocious (prespawn) gonadal tissue. more...

Organism:

Oncorhynchus mykiss; Salmo salar; Oncorhynchus tshawytscha; Coregonus clupeaformis; Osmerus mordax

Type:

Expression profiling by array

Platform:

GPL2716

24 Samples

Download data: TXT

(Submitter supplied) We previously isolated a new angiogenesis inhibitor, terpestacin, from natural products. To investigate molecular mechanism of terpestacin for its anti-angiogenic activity, we identified a cellular binding protein of terpestacin using phage display biopanning analysis. Terpestacin specifically bound to the small molecular ubiquinone binding protein (QP-C), a 13.4 kD subunit of the mitochondrial Complex III. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1818

3 Samples

Download data: GPR

(Submitter supplied) Photosynthetic microbes can produce the clean-burning fuel hydrogen using one of nature’s most plentiful resources, sunlight 1,2. Anoxygenic photosynthetic bacteria generate hydrogen and ammonia during a process known as biological nitrogen fixation. This reaction is catalyzed by the enzyme nitrogenase and consumes nitrogen gas, ATP and electrons 3. One bacterium, Rhodopseudomonas palustris, has a remarkable ability to obtain electrons from green plant-derived material 4,5 and to efficiently absorb both high and low intensity light energy to form ATP 6. more...

Organism:

Rhodopseudomonas palustris

Type:

Expression profiling by array

Platform:

GPL3954

14 Samples

Download data: CEL, EXP