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Systematic Analysis of Transcription Factors Binding to Noncoding Variants

(Submitter supplied) A large number of sequence variants have been linked to complex human traits and diseases, but deciphering their biological functions is still challenging since most of them reside in the noncoding DNA. To fill this gap, we have systematically assessed the binding of 270 human transcription factors (TF) to 95,886 noncoding variants in the human genome using an ultra-high-throughput multiplex protein-DNA binding assay, termed SNP evaluation by Systematic Evolution of Ligands by EXponential enrichment (SNP-SELEX). more...
Organism:
synthetic construct; Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other
4 related Platforms
11359 Samples
Download data: BW, HIC, NARROWPEAK, TSV, TXT, VCF
Series
Accession:
GSE118725
ID:
200118725

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