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Chromosomal duplications increase gene dosage and mRNA level in C. elegans

(Submitter supplied) Isolation of copy number variations and chromosomal duplications at high frequency in Caenorhabditis elegans suggested that this organism tolerates dosage problems. Here we addressed if this tolerance is due to a genome-wide compensation mechanism acting at the level of mRNA expression. We characterized several chromosomal duplication strains using DNA-seq and analyzed gene expression in two duplication and a fosmid integration strain using mRNA-seq. more...
Organism:
Caenorhabditis elegans
Type:
Other; Expression profiling by high throughput sequencing
Platforms:
GPL24892 GPL15716 GPL19757
41 Samples
Download data: BEDGRAPH, TAB
Series
Accession:
GSE198682
ID:
200198682

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