GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Rattus norvegicus; Macaca mulatta; Homo sapiens

Type:

Non-coding RNA profiling by array

Platforms:

GPL26659 GPL26525

355 Samples

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(Submitter supplied) This study compared global multi-walled carbon nanotube (MWCNT)-induced miRNA expression from human lung epithelial and microvascular endothelial cells in monoculture and coculture with miRNA expression from mouse lungs exposed to MWCNT. The concordant miRNA in human cell lines, mouse lung tissues and blood will be potential biomarkers for occupational and medical surveillance.

Organism:

Rattus norvegicus; Homo sapiens; Mus musculus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL26659

72 Samples

Download data: TXT

(Submitter supplied) MicroRNA array data for 144 Mouse lung tissue RNA samples were processed, out of which, 139 passed the visual Quality Control (QC) and data QC. To determine potential signaling pathways involved with MWCNT-associated pathological changes in comparison to asbestos, we determined up- and down-regulated miRNA expression in lung tissue at 1 year post-exposure.

Organism:

Homo sapiens; Macaca mulatta; Mus musculus; Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL26525

139 Samples

Download data

(Submitter supplied) Pulmonary exposure to multiwalled carbon nanotubes (MWCNT) induces an inflammatory and rapid fibrotic response, although the long-term signaling mechanisms are unknown. The aim of this study was to examine the effects of 1, 10, 40, or 80 μg MWCNT administered by pharyngeal aspiration on bronchoalveolar lavage (BAL) fluid for polymorphonuclear cell (PMN) infiltration, lactate dehydrogenase (LDH) activity, and lung histopathology for inflammatory and fibrotic responses in mouse lungs 1 mo, 6 mo, and 1 yr postexposure. more...

Organism:

Macaca mulatta; Homo sapiens; Mus musculus; Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL26525

144 Samples

Download data: TXT

(Submitter supplied) There is a current interest in reducing the in vivo toxicity testing of nanomaterials in animals by increasing toxicity testing using in vitro cellular assays; however, toxicological results are seldom concordant between in vivo and in vitro models. This study compared global multi-walled carbon nanotube (MWCNT)-induced gene expression from human lung epithelial and microvascular endothelial cells in monoculture and coculture with gene expression from mouse lungs exposed to MWCNT. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13607

72 Samples

Download data: TXT

(Submitter supplied) Pulmonary exposure to multiwalled carbon nanotubes (MWCNT) induces an inflammatory and rapid fibrotic response, although the long-term signaling mechanisms are unknown. The aim of this study was to perform genome-wide mRNA profiling in mice blood to identify non-invasive blood based biomarkers for medical and occupational surveillance. The pathological results in this 1-year MWCNT post-exposure study was previously published in Snyder-Talkington et al. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL17400

144 Samples

Download data: CEL