GEO DataSet Links for PMC (Select 6527870) - GEO DataSets

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Items: 2

Select item 2001153651.

MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation

(Submitter supplied) The MYC oncoprotein binds to promoter-proximal regions of virtually all transcribed genes and is expressed in a strictly growth factor-dependent manner in non-tumor cells. Here we show that MYC directly binds SPT5, a subunit of the RNA polymerase II (POL2) elongation factor DSIF. MYC recruits SPT5 to genes and enables the CDK7-dependent transfer of SPT5 onto POL2. Consistent with known functions of SPT5, MYC is required for fast and processive transcription elongation. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platform:: GPL18573
47 Samples

Download data: BEDGRAPH

Series

Accession:: GSE115365

ID:: 200115365

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001138612.

Nascent RNA Sequencing after NMYC activation in SH-EP MYCNER cells

(Submitter supplied) In order to distinguish transcription changes from RNA modification and post transcription changed, nascent RNA seq via metabolic labeling of freshly synthesized RNA was carried out using 4sU labeling/biotin purification.