GEO DataSet Links for PMC (Select 6387548) - GEO DataSets

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Items: 2

Select item 2001090081.

LincK promotes proliferation and epithelial-to-mesenchymal transition and contributes to tumorigenesis and growth in breast cancer II

(Submitter supplied) We previously reported that transwell co-culture with hAD-MSCs cells can induce an EMT progress in MCF7 cells. To identify EMT-relevant lncRNAs, we conducted transcriptome microarray analysis of MCF7 cells at Day 0, 2, 4, 6, 8 and 10 after coculture.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL19072
6 Samples

Download data: TXT

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Accession:: GSE109008

ID:: 200109008

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001090072.

LincK promotes proliferation and epithelial-to-mesenchymal transition and contributes to tumorigenesis and growth in breast cancer I

(Submitter supplied) In this study, we aimed to identify potential lncRNA deregulations associated with breast cancer malignancy instigated by MSCs-MCF7 co-culture. We profiled expression changes of lncRNAs in MCF-7 cells during EMT induced by coculture with hAD-MSCs, and found an intergenic lncRNA with proviouly unknown function (KB-1732A1.1, we termed it LincK), which was significantly elevated. Depletion of LincK decreased the growth, migration, invasion, and EMT in breast cancer cells, while overexpression of LincK exerted the opposite effects. more...