GEO DataSet Links for PMC (Select 3358494) - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Links from PMC

Items: 2

Select item 2000353321.

Stem cell factor programs the mast cell activation phenotype

(Submitter supplied) Mast cells, activated by antigen via the high affinity receptor for IgE (FcεRI), release an array of pro-inflammatory mediators that contribute to allergic disorders such as asthma and anaphylaxis. The KIT ligand, stem cell factor (SCF), is critical for mast cell expansion, differentiation and survival, and, under acute conditions, enhances mast cell activation. However, extended SCF exposure in vivo conversely protects against fatal antigen-mediated anaphylaxis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4420
Platform:: GPL1261
12 Samples

Download data: CEL, CHP

Series

Accession:: GSE35332

ID:: 200035332

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 44202.

Stem cell factor effect on bone marrow-derived mast cells

Analysis of bone marrow-derived mast cells (MC) treated with interleukin 3 (IL3) or IL3 + stem cell factor (SCF). MCs chronically exposed to SCF have a greatly reduced capacity to degranulate and to generate cytokines in response to antigen. Results provide insight into role of SCF in MC activation.