GEO DataSet Links for PMC (Select 3169535) - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Links from PMC

Items: 2

Select item 2000164161.

Expression data from human primary fibroblasts treated with Trypanosoma cruzi-conditioned medium

(Submitter supplied) The intracellular pathogen Trypanosoma cruzi secretes an activity that blocks TGF-β-dependent induction of connective tissue growth factor (CTGF/CCN2). Here, we address the mechanistic basis for T. cruzi-mediated interference of CTGF/CCN2 expression by examining host cell signaling pathways and the global inhibitory effect on TGF-β-dependent gene expression. We show that the expression of a discrete subset of TGF-β-inducible genes involved in cell proliferation, wound repair, and immune regulation are blocked by the soluble T. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4574
Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE16416

ID:: 200016416

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 45742.

Transforming growth factor-β effect on fibroblasts in the presence of Trypanosoma cruzi conditioned medium

Analysis of fibroblasts stimulated with TGF-β in the presence of T. cruzi-conditioned medium (PCM). A soluble factor(s) from T. cruzi inhibits TGF-ß-induced MAP kinase activation. Results provide insight into the ability of secreted parasite molecules to hinder agonist-induced host cell signaling.