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Drosophila MSL complex globally acetylates H4 Lys16 on the male X chromosome for dosage compensation

(Submitter supplied) Drosophila MSL complex binds the single male X chromosome to upregulate gene expression to equal that from the two female X chromosomes. However, it has been puzzling that ~25% of transcribed genes on the X do not stably recruit MSL complex. Here, we find that almost all active genes on the X are associated with robust H4 Lys16 acetylation (H4K16ac), the histone modification catalyzed by MSL complex. more...
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL5636
8 Samples
Download data: PAIR
Series
Accession:
GSE14884
ID:
200014884

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