GEO DataSets

(Submitter supplied) Active suppression of tumor-specific T lymphocytes can limit the immune-surveillance and immunotherapy efficacy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governing their immunosuppressive activity remain elusive. Here we describe a population of circulating CD11b+/IL-4Rα+, inflammatory-type monocytes that is elicited by growing tumors and activated by IFN-γ released from T lymphocytes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2454

Platform:

GPL81

9 Samples

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Analysis of CD11b+ splenocytes from tumor-bearing animals. Tumor development often leads to the accumulation of CD11b+ GR-1 myeloid cells. Results provide insight into the molecular basis of the immunosuppressive activity exhibited by tumor-induced CD11b+ splenocytes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 2 growth protocol sets

Platform:

GPL81

Series:

GSE5455

9 Samples

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