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Full record GDS3985

TGF-beta/Smad3 signaling blockade effect on white adipose tissue

Analysis of WAT from high fat diet-fed Smad3-/- mice and anti-TGF-beta antibody-treated, diet-induced obese (DIO) mice. Smad3 loss protects against DIO and diabetes. TGF-b signaling blockade protects against obesity and diabetes. Results provide insight into molecular mechanisms underlying diabetes.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 genotype/variation, 4 protocol sets
Platform:
GPL1261
Series:
GSE28598
12 Samples
Download data: CEL, CHP

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