GEO DataSets

Expression profiling of liver from animals treated with methylprednisolone. Liver examined at various time points up to 168 hours following methylprednisolone treatment. Results provide insight into prednisone pharmacodynamics.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 11 time sets

Platform:

GPL341

Series:

GSE487

44 Samples

Download data: CEL

(Submitter supplied) Summary: The liver is the major site of gluconeogenesis, fat processing and distribution, as well as drug and xenobiotic metabolism. Altered gene expression in the liver is centrally invovled in both the immuosuppressive and the energetic actions of corticosteroids. Hypothesis: That pharmacodynamics can be derived from expression profiling data. Specific Aim: The aim of this project is to identify distinct temporal patters of RNA expression in the liver of rats following a bolus dose of the corticosteroid methylprednisolone. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS253 GDS972

Platforms:

GPL341 GPL85

91 Samples

Download data: CEL

Expression profiling of liver from animals treated with methylprednisolone. Liver examined at various time points up to 72 hours following methylprednisolone treatment. Results provide insight into prednisone pharmacodynamics.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 17 time sets

Platform:

GPL85

Series:

GSE487

46 Samples

Download data: CEL

(Submitter supplied) Synthetic glucocorticoids are used therapeutically for a variety of conditions. Both the efficacy and toxicity of corticosteroids arise from their pharmacologically exaggerated effects on target and non-target tissues. For example, beneficial effects deriving from inhibition of the immune system are accompanied by toxic side effects that include hyperglycemia, dyslipidaemia, muscle wasting, fatty liver, and an increased risk of atherosclerosis. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2688

Platform:

GPL341

44 Samples

Download data: CEL

(Submitter supplied) The aim of this project is to identify distinct temporal patterns of RNA expression in the skeletal muscle of rats following a bolus dose of the corticosteroid methylprednisolone. 51 RG_U34A chips were used over 17 time points. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS256

Platform:

GPL85

51 Samples

Download data: CEL

Analysis of skeletal muscles of adrenalectomized animals given methylprednisolone (MPL) at a constant rate of infusion for up to 7 days. Results compared to a time series experiment using a single dose of MPL. Results provide insight into the identity of genes regulated by MPL in both regimens.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 11 time sets

Platform:

GPL341

Series:

GSE5101

44 Samples

Download data: CEL

Temporal analysis of skeletal muscle response to corticosteroid methylprednisolone. Wistar rats injected with methylprednisolone and skeletal muscle analyzed at various time points up to 72 hours.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 17 time sets

Platform:

GPL85

Series:

GSE490

51 Samples

Download data: CEL

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) The project had 2 goals: 1) To evaluate the transcriptional response of 3 prototypical toxicants (Clofibrate, VPA, and DEHP) on rat lever. 2) To evaluate the impact pooling samples has on data analysis. Keywords = Clofibrate Keywords = Diethylhexyl phthalate Keywords = Phthalic acid bis(2-ethylhexyl ester) Keywords = Sodium Valproate Keywords = Valproic Acid Keywords = VPA Keywords = vehicle Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1451

Platform:

GPL85

94 Samples

Download data: CEL, CHP, EXP

Analysis of livers of Sprague-Dawley males at various time points up to 168 hours after treatment with clofibrate, diethylhexylphthalate, or valproic acid. Expression profiles from pooled and individual samples compared. Results provide insight into the impact of pooling on experimental analysis.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 agent, 2 protocol, 4 time sets

Platform:

GPL85

Series:

GSE2303

94 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) RDX (Hexahydro-1,3,5-trinitro-1,3,5-triazine) is a synthetic, high-impact, relatively stable explosive that has been in use since WWII. Exposure to RDX can occur either occupationally or through ordnance that lays unexploded on training ranges. The toxicology of RDX is dominated by acute tonic-clonic seizures at high doses, which remit when exposure is removed and internal RDX levels decrease. Sub-chronic studies have revealed few other toxic effects. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS5282 GDS5283

Platform:

GPL1355

48 Samples

Download data: CEL

Analysis of livers of males for up to 48 hours after treatment with a single, oral, nonseizure-inducing dose of 3 or 18 mg/kg hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). RDX is a synthetic, high-impact, stable explosive. Results provide insight into the acute effects of RDX on the liver.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 dose, 4 time sets

Platform:

GPL1355

Series:

GSE12196

24 Samples

Download data: CEL

Analysis of cerebral cortices of males for up to 48 hours after treatment with an oral, nonseizure-inducing dose of 3 or 18 mg/kg hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). RDX is a synthetic, high-impact, stable explosive. Results provide insight into the acute effects of RDX on the brain.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 dose, 4 time sets

Platform:

GPL1355

Series:

GSE12196

24 Samples

Download data: CEL

(Submitter supplied) Summary: To identify distinct temporal patterns of mRNA expression in the kidney of rats following a bolus dose of the corticosteroid methylprednisolone. Hypothesis: That prednisone pharmacodynamics can be derived from expression profiling data. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS964 GDS965

Platforms:

GPL341 GPL85

63 Samples

Download data: CEL

Expression profiling of kidneys from animals treated with methylprednisolone. Kidneys examined at various time points up to 6 hours following methylprednisolone treatment. Results provide insight into prednisone pharmacodynamics.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 3 time sets

Platform:

GPL85

Series:

GSE1721

10 Samples

Download data: CEL

Expression profiling of kidneys from animals treated with methylprednisolone. Kidneys examined at various time points up to 72 hours following methylprednisolone treatment. Results provide insight into prednisone pharmacodynamics.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 17 time sets

Platform:

GPL341

Series:

GSE1721

53 Samples

Download data: CEL