Similar studies for GEO DataSets (Select 5384) - GEO DataSets

Select item 53841.

Interferon-gamma effect on peripheral blood monocyte-derived dendritic cells

Analysis of monocyte-derived dendritic cells (moDC) treated with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4 or GM-CSF, IL-4 and interferon (IFN)-γ for 6d. Results provide insight into effects of IFN-γ on differentiation and maturation of peripheral blood moDC.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 individual, 2 protocol sets

Platform:: GPL6244
Series:: GSE47621
8 Samples

Download data: CEL

DataSet

Accession:: GDS5384

ID:: 5384

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000476212.

Interferon-gamma critically determines dendritic cell function

(Submitter supplied) A growing body of evidence suggests that inflammatory cytokines have a dualistic role in immunity. In this study, we sought to determine the direct effects IFN-gamma on the differentiation and maturation of human peripheral blood monocyte-derived dendritic cells (moDC). Here, we report that following differentiation of human peripheral-blood monocytes into moDCs with granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-4, interferon-gamma (IFN-gamma) induces moDC maturation and up-regulates the co-stimulatory markers CD80, CD86, CD95, and MHC Class I, enabling moDCs to effectively generate antigen-specific CD4+ and CD8+ T cell responses for multiple viral and tumor antigens. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5384
Platform:: GPL6244
8 Samples

Download data: CEL, TXT

Series

Accession:: GSE47621

ID:: 200047621

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000398633.

Role of interleukin-4 in the licensing of dendritic cells for the induction of Th2 responses

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL10333 GPL4134
6 Samples

Download data: GPR, TXT

Series

Accession:: GSE39863

ID:: 200039863

Select item 2000398624.

Role of interleukin-4 in the licensing of dendritic cells for the induction of Th2 responses [A]

(Submitter supplied) T helper type 2 (Th2) responses are crucial for defense against infections by helminths and are responsible for the development of allergic reactions that can lead to severe clinical disorders, such as asthma or anaphylaxis, and ultimately to death. The induction of Th2 responses requires a specific activation process, triggered by specialized dendritic cells (DCs), by which naive CD4+ Th0 cells acquire the capacity to produce Th2 cytokines. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
4 Samples

Download data: GPR

Series

Accession:: GSE39862

ID:: 200039862

Select item 2000398585.

Role of interleukin-4 in the licensing of dendritic cells for the induction of Th2 responses [B]

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10333
2 Samples

Download data: TXT

Series

Accession:: GSE39858

ID:: 200039858

Select item 2001115816.

Molecular signatures of maturing dendritic cells: implications for testing the quality dendritic cell therapies

(Submitter supplied) Abstract Background: Dendritic cells (DCs) are often produced by granulocyte-macrophage colony-stimulating factor (GMCSF) and interleukin-4 (IL-4) stimulation of monocytes. To improve the effectiveness of DC adoptive immune cancer therapy, many different agents have been used to mature DCs. We analyzed the kinetics of DC maturation by lipopolysaccharide (LPS) and interferon-g (IFN-g) induction in order to characterize the usefulness of mature DCs (mDCs) for immune therapy and to identify biomarkers for assessing the quality of mDCs. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL24704
24 Samples

Download data: GPR

Series

Accession:: GSE111581

ID:: 200111581

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000663857.

Allogeneic mature human dendritic cells generate superior alloreactive regulatory T cells in the presence of IL-15

(Submitter supplied) Introduction: Expansion of antigen (Ag)-specific natural occurring regulatory T cells (nTregs) is required to obtain sufficient numbers of cells for cellular immunotherapy. In this study, different allogeneic stimuli were studied for their capacity to generate functional alloAg-specific nTregs. Methods: A highly enriched nTreg-fraction (CD4+CD25brightCD127- T cells) was alloAg-specific expanded using HLA-mismatched immature, mature monocyte-derived dendritic cells (moDC) or peripheral blood mononuclear cells (PBMC). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
11 Samples

Download data: TXT

Series

Accession:: GSE66385

ID:: 200066385

Select item 2002504638.

Cystatin from the helminth Ascaris lumbricoides (Al-CPI) upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells (moDC)

(Submitter supplied) Background: Ascaris lumbricoides cystatin (Al-CPI) prevents development of allergic airway inflammation and colitis in mice models. It has been suggested that helminth derived cystatins inhibit cathepsins in dendritic cells (DC), but their immunomodulatory mechanisms are unclear. We aimed to analyze the transcriptional profile of human monocyte derived DC (moDC) upon stimulation with Al-CPI to elucidate target genes and pathways of parasite immunomodulation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21697
42 Samples

Download data: TXT

Series

Accession:: GSE250463

ID:: 200250463

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002070639.

Production of MHCII-expressing classical monocytes increases during aging in mice and humans

(Submitter supplied) Aging is associated with increased monocyte production and altered monocyte function. Classical monocytes are heterogenous and a shift in their subset composition may underlie some of their apparent functional changes during aging. We have previously shown that mouse granulocyte-monocyte progenitors (GMPs) produce “neutrophil-like” monocytes (NeuMo), whereas monocyte-dendritic cell progenitors (MDPs) produce monocyte-derived dendritic cell (moDC)-producing monocytes (DCMo). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE207063

ID:: 200207063

PubMed Full text in PMC Similar studies

Select item 20022340010.

NanoSTRING analysis of sorted monocytes/monoACT cells following radiotherapy

(Submitter supplied) The recruitment of monocytes and their differentiation into immunosuppressive cells is associated with the negative outcome of non-conformal radiotherapy (RT). However, non-conformal RT is irrelevant in the clinic, and little is known about the role of monocytes following radiotherapy modes used in patients, such as conformal radiotherapy (CRT). Here, we investigated the acute immune infiltration post-CRT. more...