GEO DataSets

Analysis of pigmented melanoma G3361 cell line following ABCB5 ablation. ABCB5 [ATP-binding cassette, subfamily B (MDR/TAP), member 5] is a drug efflux transporter shown to be highly overexpressed in diverse human cancers. Results provide insight into the role of ABCB5 in melanoma.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL571

Series:

GSE38290

6 Samples

Download data: CEL, EXP, TXT

(Submitter supplied) Functional analysis of ABCB5 in A375 and G3361 melanoma cells, by comparing stably-transfected controls to ABCB5-shRNA-targeted cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS5317 GDS5318

Platform:

GPL571

12 Samples

Download data: CEL, EXP, TXT

Analysis of nonpigmented melanoma A375 cell line following ABCB5 ablation. ABCB5 [ATP-binding cassette, subfamily B (MDR/TAP), member 5] is a drug efflux transporter shown to be highly overexpressed in diverse human cancers. Results provide insight into the role of ABCB5 in melanoma.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL571

Series:

GSE38290

6 Samples

Download data: CEL, EXP, TXT

(Submitter supplied) Melanoma growth is driven by malignant melanoma initiating cells (MMIC) identified by expression of the ATP-binding cassette (ABC) member, ABCB5. ABCB5+ melanoma subpopulations have been shown to overexpress the vasculogenic differentiation markers CD144 (VE-cadherin) and TIE-1 and are associated with CD31-negative vasculogenic mimicry (VM), an established biomarker associated with increased patient mortality. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

10 Samples

Download data: CEL, CHP

(Submitter supplied) Melanoma remains the most lethal skin cancer, mainly because of high resistance to therapy. Side population (SP) cells are found in many types of cancer and are usually enriched in therapy-resistant as well as tumorigenic cells. Here, we identified a Hoechst dye-effluxing SP in a large series of human melanoma samples representing different progression phases. The SP size did not change with disease stage but was correlated with the prognostic “Breslow’s depth” in the primary (cutaneous) tumors. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

8 Samples

Download data: TXT

(Submitter supplied) Defining markers of different phenotypic states in melanoma is important for understanding disease progression, determining the response to therapy, and defining the molecular mechanisms underpinning phenotype-switching driven by the changing intratumor microenvironment. The ABCB5 transporter is implicated in drug-resistance and has been identified as a marker of melanoma-initiating cells. Indeed, ongoing studies are using ABCB5 to define stem cell populations. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

6 Samples

Download data: XLSX

(Submitter supplied) Here we report the beneficial effects of a newly identified dermal cell subpopulation expressing the ATP-binding cassette subfamily B member 5 (ABCB5) for the therapy of non-healing wounds. Local administration of dermal ABCB5+-derived MSCs attenuated macrophage-dominated inflammation and thereby accelerated healing of full-thickness excisional wounds in the iron overload mouse model mimicking the non-healing state of human venous leg ulcers. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

9 Samples

Download data: CSV

(Submitter supplied) Background: Cancer stem cells are presumed to have virtually unlimited proliferative and self-renewal abilities and to be highly resistant to chemotherapy, a feature that is associated with overexpression of ATP-binding cassette transporters. We investigated whether prolonged continuous selection of cells for drug resistance enriches cultures for cancer stem-like cells. Methods: Cancer stem cells were defined as CD44+/CD24– cells that could self-renew (ie, generate cells with the tumorigenic CD44+/CD24– phenotype), differentiate, invade, and form tumors in vivo. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4084

Platform:

GPL571

4 Samples

Download data: CEL

Analysis of weakly tumorigenic parental MCF-7 cells and a multistep doxorubicin-selected MCF-7/ADR subline. Results provide insight into whether prolonged continuous selection of cells for drug resistance enriches for cancer stem-like cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell line, 2 genotype/variation sets

Platform:

GPL571

Series:

GSE24460

4 Samples

Download data: CEL

(Submitter supplied) Gene expression profiling of ABCB1 positive and ABCB1 negative OCM1A cells. ABCB1 is an ATP-dependent transporter efflux pump. OCM1A cell line is derived from uveal melanomas.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6883

6 Samples

Download data: TXT