GEO DataSets

Analysis of cisplatin-resistant lung cancer cells derived from the non-small cell lung cancer (NSCLC) cell line H460. Results provide insight into the molecular mechanisms underlying the development of cisplatin resistance in NSCLC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell line sets

Platform:

GPL6244

Series:

GSE21656

6 Samples

Download data: CEL, CHP

(Submitter supplied) Combination of platinum-based chemotherapy and radiation is currently the standard treatment for locally advanced lung cancer patients. However, therapeutic resistance to these therapies may arise from the presence of cancer stem cells (CSCs). To investigate the CSCs hypothesis of chemo-radiation resistance, we used microarray assay to profile CSCs-like cisplatin-resistant lung cancer cells (CDDP-R) versus its parental cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5247

Platform:

GPL6244

6 Samples

Download data: CEL, CHP

(Submitter supplied) KIAA1522 is aberrantly over-expressed and predicts the outcome of platinum-base chemotherapy. Down-regulation of KIAA1522 sensitizes lung adenocarcinoma cells to cisplatin. To evaluate the molecular mechanisms underlying KIAA1522-induced cisplatin resistance. The RNA sequencing assays were performed in KIAA1522-depleted 889 cells.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

6 Samples

Download data: TXT

(Submitter supplied) A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation. A kinome-wide siRNA screen identified a role for Insulin Receptor (InsR) in the hormone-independent growth of ER+ breast cancer cells We used gene expression microarrays to identify genes and pathways that are altered by insulin stimulation of ER+ MCF-7 human breast cancer cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13158

9 Samples

Download data: CEL, CHP