GEO DataSets

Analysis of kidney from 8-24 week-old, Nr4a1-deficient (Nr4a1−/−) animals developed on the genetic background of the Fawn-Hooded Hypertensive (FHH) rat. The FHH model is susceptible to kidney injury. Results provide insight into the role of Nr4a1 in the pathogenesis of kidney disease.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 3 time sets

Platform:

GPL6247

Series:

GSE54714

18 Samples

Download data: CEL, CHP

(Submitter supplied) Nr4a1 deficient rats (Nr4a1-/-) were developed using the fawn hooded hypertensive rat (FHH), which provided a genetic background susceptible to kidney injury. Both groups of animals were evaluated for blood pressure, proteinuria, renal function, and whole transcriptome gene pathway changes. Gene expression profiling was performed at week 8, 16, and 24 using kidney from FHH and Nr4a1-/- rats. To identify differentially expressed gene between FHH and Nr4a1-/- two statistical methods were utilized: (1) FWER (family-wise error rate) procedure, p<0.05 and fold-change ±1.2 or greater; and/or (2) Benjamani and Hochberg FDR (false discovery rate) using p<0.05, and fold-change ±1.2 or greater. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS5223

Platform:

GPL6247

18 Samples

Download data: CEL, CHP

(Submitter supplied) NR4A nuclear receptors are known tumor suppressors of acute myeloid leukemia and are essential regulators of hematopoietic stem cell (HSC) quiescence. To study the transcriptional consequences of acute NR4A1/3 codepletion in HSCs, we used an Nr4a1/3 conditional knockout mouse model and performed a global transcriptome profiling using RNA-Seq in sorted HSCs four days after NR4A1/3 codepletion.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

6 Samples

Download data: TXT

(Submitter supplied) The nuclear orphan receptor Nur77 (NR4A1, TR3, or NGFI-B) has been shown to exhibit an anti-inflammatory function in macrophages. To further elucidate the role of Nur77 in macrophage physiology, we compared the transcriptome of bone marrow-derived macrophages (BMM) from wild-type (WT) and Nur77-knockout (KO) mice both before and after stimulation with IL4 or LPS.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

18 Samples

Download data: TXT

(Submitter supplied) Microarray was performed on kidneys of Fawn-Hooded Hypertensive (FHH) rats in order to elucidate the so-called "beneficial" effect of perinatal treatment with PDTC.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

59 Samples

Download data: TXT