GEO DataSets

Analysis of A549 cells treated with SiO2 NPs (diameters of 9nm and 18nm) and examined after 3hr and 22hr recovery times. Coated nanomaterials (e.g., SiO2 NPs) agglomerate less and are, thus, more easily inhalable. Results provide molecular insight into molecular basis of nanotoxicological effects.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 agent, 2 time sets

Platform:

GPL6480

Series:

GSE53700

18 Samples

Download data: TXT

(Submitter supplied) Expansion of nanotechnology will bring many potential benefits as adversely effects on human health. Protection of the human respiratory system from exposure of volatile nanoparticles has become an emerging health concern. The understanding of the biological processes involved in the development and maintenance of a variety of pathologies is improved by genome-wide approaches. Technical feasibility of this type of experiment has perfected in recent years, but data analysis remains challenging. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5206

Platform:

GPL6480

18 Samples

Download data: TXT

(Submitter supplied) Using a macrophage cell line, we demonstrate the ability of amorphous silica particles to stimulate inflammatory protein secretion and induce cytotoxicity. Whole genome microarray analysis of early gene expression changes induced by 10nm and 500nm particles showed that the magnitude of change for the majority of genes correlated more tightly with particle surface area than either particle mass or number. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

21 Samples

Download data: CEL

(Submitter supplied) We have employed whole genome microarray expression to distinguish the effect of Fumed Silica Nanoparticles on human alveolar epithelial A549 lung cells. Cells were exposed in vitro, and datasets of differentially expressed genes were identified for NPs versus control samples.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

38 Samples

Download data: TXT

(Submitter supplied) Gene expression profiling of the human keratinocytes cell line (HaCaT) exposure to ultrafine, fine, and submicron TiO2 particles were employed to gain insights into the molecular events.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

12 Samples

Download data: TXT