GEO DataSets

Analysis of spinal cord from 3 week-old male Wistar pups treated daily with acrylamide (30 mg/kg) for 21 days. Acrylamide is a type-2 alkene monomer with established human neurotoxic effects. Results provide insight into the molecular basis of acrylamide neurotoxicity in developing nervous tissue.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL1355

Series:

GSE29004

4 Samples

Download data: CEL, CHP

(Submitter supplied) Acrylamide is a type-2 alkene monomer with established human neurotoxic effects. While the primary source of human exposure to acrylamide is occupational, other exposure sources include food, drinking water, and smoking. In this study, neurobehavioral assays coupled with transcriptional profiling analysis were conducted to assess both behavioral and gene expression effects induced by acrylamide neurotoxicity in rats when administered during early postnatal life. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS4612 GDS5031 GDS5032

Platform:

GPL1355

12 Samples

Download data: CEL, CHP

Analysis of sciatic nerve from 3 week-old male Wistar pups treated daily with acrylamide (30 mg/kg) for 21 days. Acrylamide is a type-2 alkene monomer with established human neurotoxic effects. Results provide insight into the molecular basis of acrylamide neurotoxicity in developing nervous tissue.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL1355

Series:

GSE29004

4 Samples

Download data: CEL, CHP

Analysis of cerebellum from 3 week-old male Wistar pups treated daily with acrylamide (30 mg/kg) for 21 days. Acrylamide is a type-2 alkene monomer with established human neurotoxic effects. Results provide insight into the molecular basis of acrylamide neurotoxicity in developing nervous tissue.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL1355

Series:

GSE29004

4 Samples

Download data: CEL, CHP

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL