GEO DataSets

Analysis of pancreas from streptozotocin-injected female offspring of low protein-fed dams. These offspring fail to regenerate their β-cells following depletion with STZ. Results provide insight into molecular basis of failed β-cell regeneration in offspring of protein-restricted pregnant mice.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 growth protocol, 2 protocol sets

Platform:

GPL1261

Series:

GSE38215

11 Samples

Download data: CEL

(Submitter supplied) Low protein (LP) during gestation leads to low birth weight and poor fetal growth, with altered islet development and glucose intolerance in adulthood. Additionally, LP offspring fail to regenerate their β-cells following depletion with streptozotocin (STZ), in contrast to control-fed offspring that are capable of β-cell regeneration. Our objective was to identify genes and signalling pathways that may be critically altered in LP offspring rendering them susceptible to develop long term glucose intolerance and decreased β-cell plasticity.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4949

Platform:

GPL1261

11 Samples

Download data: CEL

(Submitter supplied) TGFbi (transforming growth factor-beta-induced) is a secreted protein and is capable of binding to both extracellular matrix (ECM) and cells. It thus acts as a bifunctional molecule enhancing ECM and cell interactions, a lack of which results in dysfunction of many cell types. In this study, we investigated the role of TGFbi in the function and survival of islets. Based on DNA microarray analysis followed by qPCR confirmation, the TGFbi gene showed drastic increases in expression in islets after culture. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3991

Platform:

GPL1261

17 Samples

Download data: CEL

Analysis of pancreatic islet beta-cells harvested at 0 h, 24 h and 48 h after culture. Results provide insight into molecules that are detrimental to or protective of islet survival after their isolation.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 time sets

Platform:

GPL1261

Series:

GSE27547

17 Samples

Download data: CEL

(Submitter supplied) To elucidate the mechanisms involved in the acquisition of a fully differentiated beta-cell phenotype, we compared by microarray the mRNAs and the long non-coding RNAs expressed in newborn and adult rat islets.

Organism:

Rattus norvegicus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL15690

6 Samples

Download data: TXT, XLS

(Submitter supplied) Early life nutritional imbalances are risk factors for metabolic dysfunctions in adulthood, but the effects of perinatal exposure to high versus low protein diets are poorly understood. We exposed C57BL/6 offspring to a high protein/low carbohydrate (HP/LC) or low protein/high carbohydrate (LP/HC) diet during gestation and lactation, and measured metabolic phenotypes between birth and ten months of age in male offspring. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

79 Samples

Download data: CEL