GEO DataSets

Analysis of cochlea from old CBA females and males with mild or severe age-related hearing loss (presbycusis). The CBA strain it loses its hearing progressively over its lifetime. Results provide insight into the molecular mechanisms underlying presbycusis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 age, 4 disease state, 2 gender sets

Platform:

GPL339

Series:

GSE49543

41 Samples

Download data: CEL, CHP

(Submitter supplied) Presbycusis – age-related hearing loss – is the number one communicative disorder of our aged population. Here we analyzed gene expression for a set of GABA receptors in the cochlea of aging CBA mice using the Affymetrix GeneChip MOE430A. Functional phenotypic hearing measures distortion-product otoacoustic emission (DPOAE) amplitudes (four age groups) were made. The gene expression changes from RMA normalized microarray data (40 replicates) were first subjected to one-way ANOVA, and then linear regression was performed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4925

Platform:

GPL339

41 Samples

Download data: CEL, CHP, XLS

(Submitter supplied) Presbycusis is characterized by an age-related progressive decline of auditory function, and arises mainly from the degeneration of hair cells or spiral ganglion (SG) cells in the cochlea. Here we show that caloric restriction suppresses apoptotic cell death in the mouse cochlea and prevents late onset of presbycusis. Caloric restricted mice, which maintained body weight at the same level as that of young control (YC) mice, retained normal hearing and showed no cochlear degeneration. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2681

Platform:

GPL1261

9 Samples

Download data: CEL

Analysis of cochleas of 15 month old C57BL/6 (B6) animals on a calorie restricted diet. The B6 strain is a model of age-related hearing loss or presbycusis. Caloric restriction (CR) prevents late-onset presbycusis in B6. Results provide insight into the molecular basis of this effect of CR.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 2 protocol sets

Platform:

GPL1261

Series:

GSE4786

9 Samples

Download data: CEL

(Submitter supplied) Regular exercise significantly slowed age-related hearing loss (AHL) and cochlear degeneration in a well- established murine model.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL20775

10 Samples

Download data: CEL

(Submitter supplied) To identify which miRNAs are involved in the onset and progression of age-related hearing loss in the mammalian cochlea We used miRNA microarrays to screen miRNAs which exhibit the differential expression in the expressing levels during aging of the cochlea

Organism:

Mus musculus; synthetic construct

Type:

Expression profiling by array

Platform:

GPL8786

18 Samples

Download data: CEL

(Submitter supplied) Age-related hearing loss (AHL) is the progressive loss of auditory function with aging. The DBA/2J (DBA) mice have been used as a model of AHL and undergoes progressive, age-related hearing loss by 12 weeks of age. Here we analyzed cochlear gene expression of 7-week-old and 36-week-old DBA mice using microarrays. Auditory brainstem response (ABR) analysis confrimed that severe age-related hearing loss occured in 36-week-old mice, whereas moderate hearing loss occured in 7-week-old mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3028

Platform:

GPL339

6 Samples

Download data: CEL

Analysis of cochleas of 7 and 36 week old DBA/2J animals. The DBA/2J animal suffers from age-related hearing loss (AHL), a progressive disease characterized by an age-associated loss of hair cells and spiral ganglion cells in the cochlea. Results provide insight into the molecular basis of AHL.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 2 disease state sets

Platform:

GPL339

Series:

GSE6045

6 Samples

Download data: CEL