GEO DataSets

Analysis of hippocampal neural progenitor cells treated with 1.7 or 5 uM KHS101. KHS101 is a synthetic 4-aminothiazole analog that induces the neuronal differentiation of neural progenitor cells. Results provide insight into the mechanism of action of KHS101.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:

GPL1355

Series:

GSE23668

4 Samples

Download data: CEL

(Submitter supplied) Adult neurogenesis occurs in mammals and provides a mechanism for continuous neural plasticity in the brain.However, little is known about the molecular mechanisms regulating hippocampal neural progenitor cells (NPCs) and whether their fate can be pharmacologically modulated to improve neural plasticity and regeneration. Here, we report the characterization of a unique small molecule (KHS101) that selectively induces a neuronal differentiation phenotype. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4912

Platform:

GPL1355

4 Samples

Download data: CEL

(Submitter supplied) Neural stem cells (NSCs) and progenitor cells (NPCs) are increasingly appreciated to hold great promise for regenerative medicine to treat CNS injuries and neurodegenerative diseases. However, evidence for effective stimulation of neuronal production from endogenous or transplanted NPCs for cell replacement with small molecules remains limited. To identify novel chemical entities/targets for neurogenesis, we had established a NPC phenotypic screen assay and validated it using known small-molecule neurogenesis inducers. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

24 Samples

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